alexa
Reach Us +44-1647-403003
Intra-arterial Combination Chemotherapy with Maximum Transurethral Resection of Bladder Tumour for T1 Grade 3 and T2--3N0M0 Bladder Cancers | OMICS International | Abstract
ISSN: 1948-5956

Journal of Cancer Science & Therapy
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Review Article

Intra-arterial Combination Chemotherapy with Maximum Transurethral Resection of Bladder Tumour for T1 Grade 3 and T2--3N0M0 Bladder Cancers

Kaoru Nemoto1*, Narumi Tsuboi1, Takafumi Miura1, Go Shioji1, Hiroshi Kawamata2, Susumu Okada2, Yoshiharu Ohaki3, Ryoji Kimata4 and Yukihiro Kondo4

1Department of Urology, Nippon Medical School, Chiba Hokusoh Hospital, Japan

2Department of Radiology, Nippon Medical School, Chiba Hokusoh Hospital, Japan

3Department of Pathology, Nippon Medical School, Chiba Hokusoh Hospital, Japan

4Department of Urology, Nippon Medical School, Japan

*Corresponding Author:
Kaoru Nemoto
Department of Urology, Nippon Medical School
Chiba Hokusoh Hospital, 1715 Kamagari
Inzai, Chiba 270-1694, Japan
Tel: +81-476-99-1111
Fax: +81-476-99-1903
E-mail: [email protected]

Received Date: November 17, 2011; Accepted Date: November 29, 2011; Published Date: December 01, 2011

Citation: Nemoto K, Tsuboi N, Miura T, Shioji G, Kawamata H, et al. (2011) Intraarterial Combination Chemotherapy with Maximum Transurethral Resection of Bladder Tumour for T1 Grade 3 and T2--3N0M0 Bladder Cancers. J Cancer Sci Ther 3: 235-238. doi:10.4172/1948-5956.1000096

Copyright: © 2011 Nemoto K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Purpose: We evaluated the clinical outcomes following intra-arterial chemotherapy with maximum transurethral resection of bladder tumour (TURBT) for patients with T1 grade 3 (G3) and T2--3N0M0 bladder cancers. Material and methods: Patients were 27 males and 7 females with a median age of 63.6 years. With the cooperation of an interventional radiologist, cisplatin (100 mg/m2), methotrexate (30 mg/m2) and adriamycin (20 mg/ body) were administered via a catheter in 2 cycles every 4 weeks. Results: The 5-year cancer-specific survival rate in T1 G3, T2 and T3 was 100.0%, 57.3% and 50.0%, respectively. In T2--3N0M0 cases, complete response (CR) and non-CR were seen in 13 (46.4%) and 15 cases (53.6%), respectively. Response to treatment proved to be the most significant prognostic predictor of cancerspecific survival by multivariate analysis in T2--3N0M0 cases. T2--3N0M0 cases with ?2 prognostic predictors at staging TURBT (age >70 years, male, size >3 cm and the presence of hydronephrosis) had an unfavourable outcome. There was a statistical association between the number of prognostic predictors at staging TURBT and response to treatment. Conclusion: These results suggest that our protocol prevents disease progression in T1 G3 cases, but that it is not suitable for T2--3N0M0 cases with ?2 prognostic predictors at staging TURBT.

Keywords

Share This Page
Top