alexa Intraindividual Tumor Heterogeneity in Neuroendocrine Tumors Revealed with 18F-FDG and 68Ga-DOTA-TATE PET/CT
ISSN: 2155-9619

Journal of Nuclear Medicine & Radiation Therapy
Open Access

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Case Report

Intraindividual Tumor Heterogeneity in Neuroendocrine Tumors Revealed with 18F-FDG and 68Ga-DOTA-TATE PET/CT

Emre Demirci1*, Betül Vatankulu2, Resit Akyel2, Fuat Dede3 and Metin Halac2

1Department of Nuclear Medicine, Sisli Etfal Training and Research Hospital, Istanbul, Turkey

2Department of Nuclear Medicine, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey

3Department of Nuclear Medicine Marmara Medical School, Istanbul, Turkey

*Corresponding Author:
Emre Demirci, M.D
Department of Nuclear Medicine
Sisli Etfal Training and Research Hospital
Istanbul, Turkey
Tel: +90 (212) 3735000
Email: [email protected]

Received date: December 19, 2015 Accepted date: January 27, 2016 Published date: January 31, 2016

Citation: Demirci E, Vatankulu B, Akyel R, Dede F, Halac M (2016) Intraindividual Tumor Heterogeneity in Neuroendocrine Tumors Revealed with 18F-FDG and 68Ga-DOTA-TATE PET/CT. J Nucl Med Radiat Ther 7:277. doi:10.4172/2155-9619.1000277

Copyright: © 2016 Demirci E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License; which permits unrestricted use; distribution; and reproduction in any medium; provided the original author and source are credited.



68Ga-DOTA-TATE PET/CT is widely used in functional imaging of neuroendocrine tumors (NETs) and is superior to conventional somatostatin receptor scintigraphy (SRS), which is recommended for low grade NETs according to NANETS/ENETS guidelines. On the contrary 18F-FDG PET is suggested in patients with high grade NETs or when SRS is negative. However, tumor heterogeneity is a common finding along with NETs and causes differential expression of somatostatin receptor (sstr) and various FDG metabolisms. Here, we present a case where tumor heterogeneity is revealed with combined use of 18F-FDG PET/CT and 68Ga-DOTA-TATE PET/CT in the same patient and how does it influence clinical decision-making Conclusion: We here present the first report of FFF-VMAT achieving a comparable plan quality with less delivery time to that of FF-VMAT and HT in head and neck cancer. FFF-VMAT is a highly efficient and feasible option for the treatment of head and neck cancer in clinical practice.


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