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Research Article
Intraocular Pressure Elevation in the Contralateral Untreated Eye Following Selective Laser Trabeculoplasty in Rabbit Eyes
| Bonnie Nga Kwan Choy1*, Catherine Kin Chiu2,3, Jennifer Wei Huen Shum1, Jian Ji4, Ai Hua Liu4, Wei Liu4 and Jimmy Shiu Ming Lai1 | |
| 1Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China | |
| 2Research Centre of Heart, Brain, Hormone and Healthy Aging, The University of Hong Kong, Hong Kong SAR, People's Republic of China | |
| 3State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong SAR, People's Republic of China | |
| 4Tianjin Medical University Eye Hospital, Tianjin, People's Republic of China | |
| Corresponding Author : | Bonnie Nga Kwan Choy Department of Ophthalmology The University of Hong Kong, Room 30, Block B, Cyberport 4 Hong Kong, People's Republic of China Tel: 852 2255-5632 Fax: 852 2255-5398 Email: [email protected] |
| Received: August 05, 2015; Accepted: September 16, 2015; Published: September 19, 2015 | |
| Citation: Choy BNK, Chiu CK, Shum JWH, Ji J, Liu AH, et al. (2015) Intraocular Pressure Elevation in the Contralateral Untreated Eye Following Selective Laser Trabeculoplasty in Rabbit Eyes. J Clin Exp Ophthalmol 6:477. doi:10.4172/2155-9570.1000477 | |
| Copyright: © 2015 Choy BNK et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |
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Abstract
Our study aimed at evaluating if a single session of unilateral selective laser trabeculoplasty would affect the intraocular pressure of the fellow untreated eye in rabbits. Eleven rabbits were involved. 360° selective laser trabeculoplasty with 532 nm frequency-doubled green Nd:YAG laser was performed over the right eyes. The mean intraocular pressure of both eyes at baseline, 3 hours, 24 hours, 3 days and 7 days after laser were measured. The baseline mean intraocular pressure of the right eye and the left eye were 8.07 ± 1.72 mmHg and 8.27 ± 1.56 mmHg respectively (p=0.78). The mean intraocular pressure of the treated eye was lower than the baseline from 3 hours through 3 days after laser, with a maximum mean decrease of 1.36 mmHg on Day 3. On the contrary, the mean intraocular pressures of the untreated eyes were higher than the baseline throughout the study, particularly at later course (1.91 mmHg on Day 3 and 1.85 mmHg on Day 7). This suggests the change of intraocular pressure in one eye after selective laser trabeculoplasty, leads to a change in the pressure of the fellow eye. It is thought that a neuronal and humoral response is triggered centrally after unilateral intraocular pressure change. The detailed mechanisms would require further studies to evaluate. The rising intraocular pressure trend in the contralateral untreated eye suggests that response may continue to exert its action for some time after the initial laser. This is the first reported study of intraocular pressure elevation of the untreated eye following contralateral selective laser trabeculoplasty.
