Intrathecal dexmedetomidine: Useful or not?
Sherif A Abdelhamid* and Mohamed H El-lakany
Lecturer of Anaesthesia and Surgical Intensive Care-Medical Research Institute-Alexandria University, Egypt
- *Corresponding Author:
- Sherif A Abdelhamid
Lecturer of Anaesthesia and
Surgical Intensive Care-Medical Research Institute-Alexandria University, Egypt
E-mail: [email protected]
Received Date: July 22, 2013; Accepted Date: September 27, 2013; Published Date: September 30, 2013
Citation: Abdelhamid SA, El-lakany MH (2013) Intrathecal dexmedetomidine: Useful or not? J Anesth Clin Res 4:351. doi: 10.4172/2155-6148.1000351
Copyright: © 2013 Abdelhamid SA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Spinal anesthesia is used commonly intra operatively. However, local anesthetics are associated with relatively short duration of action. A number of adjuvants have been used to prolong the postoperative analgesia.
Objectives: To evaluate role of dexmedetomidine added to heavy bupivacaine 0.5% intrathecally for lower abdominal surgeries. Subjects and methods: Sixty two patients were randomly divided into one of two group, Group (D) received 3.5 mL volume of 0.5% hyperbaric bupivacaine and 5 μg dexmedetomidine in 0.5 mL of preservative free normal saline intrathecally. Group (P) received 0.5 ml normal saline added to the same dose of heavy 0.5% bupivacaine and served as placebo.
Results: There was significantly less time needed to reach T8 sensory level, 2-segment regression, and time to reach Bromage 3in group (D) compared to group (P). There was significantly more time needed for first requirement of analgesia in group (D) compared to group (P). There was a significantly less analgesic dose requirement in group (D) compared to group (P).
Conclusion: Receiving Dexmedetomidine at a dose of 5 μg provides earlier sensory and motor blockade, less postoperative analgesic requirements, less shivering among patients of lower abdominal surgery under intrathecal anaesthesia with no sedation effect or neurologic complications.