alexa Intravascular Large B-Cell Lymphoma Mimicking Central Nervous System Vasculitis
ISSN: 2165-7920

Journal of Clinical Case Reports
Open Access

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Case Report

Intravascular Large B-Cell Lymphoma Mimicking Central Nervous System Vasculitis

Fischer M#1,2, Iglseder S1*, Stockhammer G1 and Pfausler B1

1Department of Neurology, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria

2Department of Anaesthesiology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany

#Equally contributed

*Corresponding Author:
Sarah Iglseder
Department of Neurology
Medical University of Innsbruck
Anichstra ße 35, 6020 Innsbruck, Austria
Tel: +43 512 504 82958
E-mail: [email protected]

Received March 01, 2016; Accepted April 09, 2016; Published April 14, 2016

Citation: Fischer M, Iglseder S, Stockhammer G, Pfausler B (2016) Intravascular Large B-Cell Lymphoma Mimicking Central Nervous System Vasculitis. J Clin Case Rep 6:767. doi:10.4172/2165-7920.1000767

Copyright: © 2016 Fischer M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Intravascular large B-cell lymphoma (IVBCL) represents a rare subtype of extranodal diffuse large B-cell lymphoma characterized by selective growth of neoplastic cells within the lumen of small and medium-sized vessels. The clinical spectrum is heterogeneous dominated by neurological and skin manifestations. Intra-vitam diagnosis still remains challenging and usually requires brain biopsy since no pathognomonic neuroradiological findings do exist for IVBCL. We report on the case of a 65-year old male patient presenting with multifocal neurological signs and symptoms including cognitive deficits, aphasia and paraparesis as leading features. Imaging findings were suggestive for cerebral vasculitis prompting initiation of steroid treatment. After initial stabilization the patient deteriorated in spite of systemic steroid treatment, developed severe sepsis and finally died from multi-organ failure. Histopathological findings revealed CD20 positive lymphoma cells in small- and middle-sized vessels of the cerebrum, the lungs and the skin diagnostic for IVBCL. This case should raise the alertness for consideration of IVBCL as a differential diagnosis resulting in early brain biopsy, if no etiology for CNS vasculitis is evident.


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