Wong KW
Cloxacillin is a commonly used antibiotic to cover suspected Gram-positive infection and methicillin sensitive Staphylococcus aureus, especially in catheter-related infection. A case of severe agranulocytosis induced by prolonged high dose intravenous cloxacillin is reported here. Changing the antibiotic here led to rapid resolution of the potentially fatal situation caused by this antibiotic. Monitoring of blood count and high index of suspicions are important.
