Investigation of Correction Method of Recovery Effect and Motion Blur for SUV Quantification in FDG PET/CT in Patients with Early Lung CancerNoriyuki Kadoya1*, Yukio Fujita1, Kengo Ito1, Suguru Dobashi2, Ken Takeda2, Kazuma Kishi3, Takaya Yamamoto1, Rei Umezawa1, Toshiyuki Sugawara1, Tomohiro Kaneta4, Haruo Matsushita1 and Keiichi Jingu1
- *Corresponding Author:
- Noriyuki Kadoya
Department of Radiation Oncology
Tohoku University School of Medicine
1-1 Seiryo-chou, Aoba-ku
Sendai 980-8574, Japan
E-mail: [email protected]
Received date: June 25, 2013; Accepted date: August 26, 2013; Published date: August 29, 2013
Citation: Kadoya N, Fujita Y, Ito K, Dobashi S, Takeda K, et al. (2013) Investigation of Correction Method of Recovery Effect and Motion Blur for SUV Quantification in FDG PET/CT in Patients with Early Lung Cancer. J Nucl Med Radiat Ther 4:162. doi:10.4172/2155-9619.1000162
Copyright: © 2013 Kadoya N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Objective: We investigated the effects of partial volume and respiratory motion using a National Electrical Manufacturers Association (NEMA) phantom and proposed a simple method for correction of maximum standardized uptake value (SUVmax) for respiratory motion in early lung cancer. Methods: The maximum recovery coefficient (RC) in static mode were measured using the NEMA phantom and a dynamic moving platform. The phantom on the platform was either at rest or moving sinusoidally along the longitudinal axis of the scanner to simulate respiratory motion. We also calculated estimated RC using our approximation. Results: RC of the sphere of 28mm in diameter decreased from 0.96 to 0.80 and 0.41 with 20 and 50 mm of motion amplitude, respectively. For the sphere of 10 mm in diameter, RC was decreased from 0.40 to 0.18 and 0.08 with 20 and 50 mm of motion amplitude, respectively. Our results showed that RC decreased with increase in motion amplitude. Average percentage differences between measurement and estimation in the sphere of 37, 28, 22, 17, 13 and 10 mm were -1.8 ± 3.7, -3.1 ± 11.3, -2.8 ± 10.5, -8.1 ± 6.6, -7.0 ± 12.3 and -1.8 ± 12.2 %, respectively. This result showed that our simple correction method could estimate SUVmax with moderate accuracy. Conclusions: Our results clearly demonstrated that RC decreases with increase in motion amplitude, as expected. Our simple correction with moderate accuracy method could not precisely estimate RC. However, the estimated values agreed with the measurements. Thus, our methods could be used in clinical practice to calculate the approximate SUVmax for lung cancer patients undergoing radiotherapy showing the malignancy grading for early lung cancer.