alexa Investigation of Drug Interaction Studies of Levocetiri
ISSN: 2329-6798

Modern Chemistry & Applications
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Research Article

Investigation of Drug Interaction Studies of Levocetirizne with HMG-CoA Reductase Inhibitors

Saeed Arayne M1, Najma Sultana2 and Nawaz M1*
1Department of Chemistry, University of Karachi, Karachi-75270, Pakistan
2Research Institute of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan
Corresponding Author : Nawaz M
Department of Chemistry
University of Karachi
Karachi-75270, Pakistan
Tel: +92-213-466-4402-03
E-mail: [email protected]
Received September 01, 2014; Accepted September 12, 2014; Published September 17, 2014
Citation: Saeed Arayne M, Sultana N, Nawaz M (2014) Investigation of Drug Interaction Studies of Levocetirizne with HMG-CoA Reductase Inhibitors. Mod Chem appl 2:134. doi: 10.4172/2329-6798.1000134
Copyright: © 2014 Saeed Arayne M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

The aim of present work is to study the in-vitro drug-drug interaction studies of levocetirizine with HMG-CoA reductase inhibitors (atorvastatin, simvastatin and rosuvastatin) in different pH environments in simulated gastric juice (pH 1) simulating full stomach juice (pH 4), blood pH (pH 7.4) and simulated GI (pH 9) at physiological temperature (37°C). The interactions were carried out using dissolution apparatus and dug contents were analyzed by UV-Visible spectrophotometer. The availability of levocetirizine in the presences of HMG-CoA reductase inhibitors were determined by deriving a simultaneous equation for two component system through modification of Beer’s law. It was observed that availability of levocetirizine after interaction with MG-CoA reductase inhibitors was increased or decreased due to the formation of charge transfer complexes between them.

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