alexa Investigation on the Interaction of 5-iodo-4-thio-2'-deoxyuridine with Human Serum Albumin: Spectroscopic and Molecular Modeling Studies | OMICS International | Abstract
ISSN: 2379-1764

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Investigation on the Interaction of 5-iodo-4-thio-2'-deoxyuridine with Human Serum Albumin: Spectroscopic and Molecular Modeling Studies

Zhang Xiao-Hui1, He Ling-shuang1, Li De-peng1, Yin Hong-Yan1, Zhang Ju-Ling2 and Ma Ke-dong1*
1College of Environment and Chemical Engineering, Dalian University, Dalian, Liaoning, 116622, China
2MOE Key laboratory of Laser Life Science, College of Biophotonics, South China Normal University, 510631, Guangzhou, China
Corresponding Author : Ma Ke-dong
College of Environment and Chemical Engineering
Dalian University, Dalian, Liaoning, 116622, China
Tel: +8615842639633
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Received: January 05, 2016; Accepted: January 19, 2016; Published: January 26, 2016
Citation: Xiao-Hui Z, Ling-shuang H, De-peng L, Ke-dong M, Hong-Yan Y, et al. (2016) Investigation on the Interaction of 5-iodo-4-thio-2’-deoxyuridine with Human Serum Albumin: Spectroscopic and Molecular Modeling Studies. Adv Tech Biol Med 4:162. doi:10.4172/2379-1764.1000162
Copyright: © 2016 Xiao-Hui Z, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Due to the special affinity on tumor cells and anti-cancer activity for 5-iodo-4-thio-2'-deoxyuridine, the interactions between 5-iodo-4-thio-2'-deoxyuridine and human serum albumin (HSA) were investigated with the fluorescence spectroscopy. The results showed that 5-iodo-4-thio-2'-deoxyuridine on human serum albumin (HSA) had a dynamic fluorescence quenching. The main forces of both interactions have typical hydrophobic interaction from thermodynamic data to determination. The conformation of 5-iodo-4-thio-2'-deoxyuridine on human serum albumin was studied using synchronous fluorescence spectroscopy. The experimental result was in correspondence with molecular modeling theory. This work would be useful to understand the state of the transportation, distribution, and metabolism of the anticancer drug in human body, these results may be of significance in pharmacology and clinical medicines.

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