alexa In-vivo Animal Models and In-vitro Techniques for Scree
ISSN: 2329-6631

Journal of Developing Drugs
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Review Article

In-vivo Animal Models and In-vitro Techniques for Screening Antidiabetic Activity

Karthikeyan M1*, Balasubramanian T1 and Pawan Kumar2

1Research Scholar ,Department of Pharmacy and Medical Sciences, School of Pharmacy and Medical Sciences, Singhania University, Pacheribari, Jhunjhunu-333 515, Rajasthan, India

2Associate professor ,Department of Pharmacology, Al Shifa College of Pharmacy, Kerala-679 325, India

3Associate Professor, Department of life Sciences, Singhania University, Pacheribari, Jhunjhunu, 333515 Rajasthan, India

*Corresponding Author:
Karthikeyan M
Research Scholar
Department of Pharmacy and Medical Sciences
School of Pharmacy and Medical Sciences
Singhania University, Pacheribari
Jhunjhunu-333 515, Rajasthan, India
Tel: +919656111669
E-mail: [email protected]

Received date: March 23, 2016; Accepted date: March 29, 2016; Published date: April 08, 2016

Citation: Karthikeyan M, Balasubramanian T, Kumar P (2016) In-vivo Animal Models and In-vitro Techniques for Screening Antidiabetic Activity. J Develop Drugs 5:153. doi:10.4172/2329-6631.1000153

Copyright: © 2016 Karthikeyan M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Diabetes mellitus is a group of metabolic disorder, is characterized by absolute by lack of insulin and resulting in hyperglycemia. About 2.8% of global populations are affected by Diabetes mellitus. The search for new drug with new properties to treat the disease is still in progress. The current review have made an attempt to bring together all reported models and advanced techniques. Experimentally diabetes mellitus is generally induced in laboratory animals by several methods that include: chemical, surgical and genetic manipulations. The various in vitro techniques includes: In-vitro studies on insulin secretion, In-vitro studies on glucose uptake, Studies using isolated pancreatic islet cell lines, Assay of Amylase Inhibition and Inhibition of α-Glucosidase Activity. Experimental induction of diabetes mellitus in animal models and in vitro techniques are essentials for the advancement of our knowledge, clear understanding of pathogenesis and for finding new therapy. The animal models and in vitro techniques are essentials for developing a new drug for the treatment diabetes. More animal models, advanced techniques have to be developed for advances in diabetes research.


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