Involvement of SIRT1 in Zn2+, Streptozotocin, Non-Obese Diabetic, and Cytokine-Mediated Toxicities of ÃÂ²-cellsChristian T. Sheline*
Louisiana State University Health Sciences Center, LA, USA
- *Corresponding Author:
- Christian T. Sheline
Department of Ophthalmology and The Neuroscience Center of Excellence
Louisiana State University Health Sciences Center
2020 Gravier St., Suite D, New Orleans
LA 70112, USA
Tel: (504) 599-0880
Fax: (504) 599-0891
E-mail: [email protected]
Received date: March 20, 2011; Accepted date: May 28, 2012; Published date: May 31, 2012
Citation: Sheline CT (2012) Involvement of SIRT1 in Zn2+, Streptozotocin, Non- Obese Diabetic, and Cytokine-Mediated Toxicities of β-cells. J Diabetes Metab 3:193.doi:10.4172/2155-6156.1000193
Copyright: © 2012 Sheline CT. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Zn2+ toxicity is implicated in pancreatic β-cell death that occurs secondarily to: streptozotocin exposure in vitro and both autoimmune attack or streptozotocin in vivo models of T1DM.