Involvement of Varicose Veins in Superficial Venous ThrombosisPavel Poredos*
University Medical Center Ljubljana, Slovenia
- *Corresponding Author:
- Pavel Poredos
University Medical Center, Ljubljana, Slovenia
E-mail: [email protected]
Received date: December 28, 2015 Accepted date: January 15, 2016 Published date: January 18, 2016
Citation: Poredos P (2016) Involvement of Varicose Veins in Superficial Venous Thrombosis. Anat Physiol 6:196. doi: 10.4172/2161-0940.1000196
Copyright: © 2016 Poredos P. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Varicose veins are usually a sign of a benign disease, however with progression of the disease and advanced age, they can lead to serious clinical problem. Beside chronic venous insufficiency, superficial venous thrombosis (SVT) represents one of the most frequent complications which can complicate with deep venous thrombosis (DVT) and pulmonary embolism. Classical risk factors for SVT are similar as for DVT. However, varicose veins represent one of the most important risk factors for the development of SVT. In varicose veins blood flow is usually turbulent, with increased shear stress which causes vascular damage, resulting in endothelial dysfunction and structural deterioration of vessel wall accompanied by inflammatory response. Because of changes in hemodynamic conditions, in varicose veins the constitution of blood is changed. In varicose veins haematocrit level is increased and consequently blood viscosity. Further, in the blood of varicose veins circulating inflammatory markers are increased, as well as circulating markers of endothelial damage. There is also imbalance between the pro-and anticoagulant factors and between pro-and antifibrinolytic agents favouring hypercoagulable microenvironment. Therefore, varicose veins represent the highest risk for development of SVT.