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ISSN-2155-9929

Journal of Molecular Biomarkers & Diagnosis
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Review Article

Iron Biomarker in Gestational Diabetes Pathogenesis

Priyanka Shukla1, Xiaoqiu Xiao2* and Rahul Mishra3

1Department of Endocrinology, First affiliated hospital of Chongqing Medical University, Chongqing, PR China

2Department of Lipid and Glucose Metabolism, First affiliated hospital of Chongqing Medical University, Chongqing, PR China

3First affiliated Hospital of Chongqing Medical University, Chongqing, PR China

*Corresponding Author:
Xiaoqiu Xiao
Laboratory of Lipid & Glucose Metabolism
The First Affiliated Hospital of Chongqing Medical University
No. 1 Youyi Road,Yuzhong District
Chongqing 400016, People’s Republic of China
Tel: +86(23)89011866
Fax: +86(23)89011865
E-mail: [email protected]

Received Date: November 07, 2014; Accepted Date: November 22, 2014; Published Date: November 25, 2014

Citation: Shukla P, Xiao X, Mishra R (2014) Iron Biomarker in Gestational Diabetes Pathogenesis. J Mol Biomark Diagn 5:205. doi:10.4172/2155-9929.1000205

Copyright: © 2014 Shukla P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Gestational diabetes mellitus (GDM) is observed to be associated with increased perinatal morbidity and mortality. Screening for glucose intolerance during pregnancy provides an opportunity to offer management to those women diagnosed with gestational diabetes mellitus after first trimester. Elevated iron stores may induce diabetes through a variety of mechanisms, including oxidative damage to pancreatic beta cells, impairment of hepatic insulin extraction by the liver, and interference with insulin's ability to suppress hepatic glucose production. Raised Serum Ferritin could be related to the occurrence of long term complications of diabetes, both micro vascular and macro vascular. Iron affects glucose metabolism and glucose metabolism impinges on several iron metabolic processes. Iron overload decreases insulin sensitivity and cause earlier complications in diabetes mellitus. Iron plays a direct and causal role in diabetes pathogenesis mediated both by cell failure and insulin resistance. Iron also regulates metabolism in most tissues involved in fuel homeostasis, with the adipocyte in particular serving an iron-sensing role.

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