Letter to Editor
Iron Overload in Two Children after Allogeneic Hematopoietic SCT with Concomitant HFE p.s65cgene Mutation
- *Corresponding Author:
- Barbara Kaczorowska-Hac
Department of Pediatrics
Hematology, Oncology and Endocrinology
Medical University of Gdansk
Debinki 7 Str, 80-952 Gdansk, Poland
E-mail: [email protected]
Received Date: November 21, 2013; Accepted Date: January 08, 2014; Published Date: January 13, 2014
Citation: Kaczorowska-Hac B, Szalewska M, Niedzwiecki M, Adamkiewicz- Drozynska E, Milosz E (2014) Iron Overload in Two Children after Allogeneic Hematopoietic SCT with Concomitant HFE p.s65cgene Mutation. J Blood Lymph 4:117. doi: 10.4172/2165-7831.1000117
Copyright: © 2014 Kaczorowska-Hac B, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Acute Myelomonoblastic Leukaemia (ANLL M4) and Aplastic Anemia (AA) are rare childhood diseases. Treatment of ANLL involves chemotherapy and radiotherapy, while immunosuppressive therapy is used in the treatment of AA. In selected cases, both disorders can be treated by performing a Hematopoietic Stem Cell Transplantation (HSCT). In addition, supportive medical care which includes antibiotics, antifungal drugs, packed red cells and platelets, is usually essential due to adverse effects caused by the therapy. Herein, we present a 15- year- old boy with ANLL M4 and a 17- year- old girl suffering from Severe Aplastic Anemia (SAA) for 3 and 4 years respectively, in whom iron overload was noted after they had undergone allogeneic HSCT (allo HSCT). On further diagnosis, co-existence of S65C HFE gene carriage was identified in both of them.