alexa Is Cardiac Stem Cell Therapy a New Horizon of Heart Reg
ISSN: 2168-9547

Molecular Biology: Open Access
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Review Article

Is Cardiac Stem Cell Therapy a New Horizon of Heart Regeneration: Literature Review

Mohammad Afaque Alam1*, Muhammad Fawad Ishfaq1 and Bushra Khanam2

1University of Tennessee Health Science Center, Memphis, TN, USA

2Birla Institute of Medical Sciences, Ranchi, India

*Corresponding Author:
Mohammad Afaque Alam
894 Union Avenue
University of Tennessee health science center Memphis
TN38163, USA
Tel: 901-518-6443
Fax: 901-518-6443
E-mail: [email protected]

Received date: March 15, 2016 Accepted date: March 18, 2016 Published date: March 25, 2016

Citation: Alam MA, Ishfaq MF, Khanam B (2016) Is Cardiac Stem Cell Therapy a New Horizon of Heart Regeneration: Literature Review. Mol Biol 5:159. doi: 10.4172/2168-9547.1000159

Copyright: © 2016 Alam MA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Improvements in the care of patients with cardiovascular disease have led to improved survival but also a burgeoning population of patients with advanced heart disease. Cardiac stem cells (CSC) continue to promise opportunities to repair damaged cardiac tissue. However, precisely how stem cells accomplish cardiac repair, especially after ischemic damage, remains controversial. It has been postulated that the clinical benefit of adult stem cells for cardiovascular disease results from the release of cytokines and growth factors by the transplanted cells, stimulation of new blood vessel growth, enhancing tissue perfusion, and via preservation or even regeneration of myocardial tissue, leading to improvements in cardiac performance after myocardial infarction and in patients with advanced heart failure, reducing inflammation, and scar formation, as well as protecting cardiomyocytes from apoptosis. In addition, reducing fibrosis these factors might also stimulate endogenous repair by activating cardiac stem cells. Interestingly, stem cells discovered to be resident in the heart appear to be functionally superior to extra-cardiac adult stem cells when transplanted for cardiac repair and regeneration. Stem cells are the seeds of tissue repair and regeneration and a promising source for novel therapies. However, apart from hematopoietic stem cell (HSC) transplantation, all other stem cell treatments however remain experimental. Mounting hopes have encouraged numerous clinical trials, but it has been difficult to obtain unequivocal evidence for robust clinical benefit. This review provides a historic framework and an abridgment of how the theories of CSC origin and potential evolved from early times to the present day. The development of more effective cardiac therapies may thus require targeting this important cell population. Here, we summarize and offer some thoughts on the state of the field of cell therapy for ischemic heart diseases and the therapeutic potential of cardiac stem cells.

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