Is CRP, like ESR, Age and Gender Dependent?
Mark Feldman* and Stephanie Sbong
Department of Internal Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, Texas, USA
- *Corresponding Author:
- Mark Feldman, MD
Chair, Department of Internal Medicine
Texas Health Presbyterian Dallas
8200 Walnut Hill Lane, Dallas, TX 75232, USA
Tel: 214 345 7881
Fax: 214 345 5167
E-mail: [email protected]
Received Date: April 07, 2014; Accepted Date: May 22, 2014; Published Date: May 29, 2014
Citation: Feldman M, Sbong S (2014) Is CRP, like ESR, Age and Gender Dependent?. Rheumatology (Sunnyvale) 4: 134. doi:10.4172/2161-1149.1000134
Copyright: © 2014 Feldman M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
C-reactive protein (CRP) and the erythrocyte sedimentation rate (ESR) are often ordered together in patients suspected of having inflammatory or infectious disorders. ESRs are higher in women than in men and they also increases with age, although most laboratory reference ranges only take gender into account. It is unclear whether CRP, like ESR, differs between women and men and/or increases with age. We analyzed 382 consecutive patients in whom the CRP and ESR were both within the laboratory’s reference range. ESR was, as expected, ≈5 mm/h higher in the 236 women than in the 146 men (P<0.0001). ESR was significantly correlated with patient age (P=0.0012). In contrast to ESR, CRP levels were identical in women and men and there was no correlation between CRP and patient age. Thus, laboratories should adjust the ESR reference range for gender and age, but this adjustment is not necessary for CRP.