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Is Folate an Aetiological Factor for Colorectal Cancer Onset? A Case- Control Study | OMICS International | Abstract
ISSN: 2161-0444

Medicinal Chemistry
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Research Article

Is Folate an Aetiological Factor for Colorectal Cancer Onset? A Case- Control Study

Asma Kassab1, Awatef Msolly1*, Shunji Fujimori2, Ramzi Lakhdar3 and Abdelhedi Miled1

1Biochemistry laboratory, Farhat Hached University Hospital, Sousse, Tunisia

2Department of Gastroenterology, Nippon Medical School, Graduate school of medicine, Tokyo, Japan

3Department of Biochemistry and Molecular Biology, Pharmaceutical Faculty, Monastir, Tunisia

*Corresponding Author:
Awatef Msolly
Dental faculty
Department of Biochemistry
5000 Monastir, Tunisia
Tel: 00216 97 86 71 55
E-mail: [email protected]

Received date: June 27, 2014; Accepted date: July 23, 2014; Published date: July 25, 2014

Citation: Kassab A, Msolly A, Fujimori S, Lakhdar R, Miled A (2014) Is Folate an Aetiological Factor for Colorectal Cancer Onset? A Case-Control Study. Med chem 4:569-572. doi:10.4172/2161-0444.1000195

Copyright: © 2014 Kassab A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


The aim of this study was to investigate the correlation of serum folate concentration in newly diagnosed patients with colorectal cancer. Patient population consisted of 101 sporadic colon cases, newly diagnosed, non-alcoholic and non-multivitamins users. Control population consisted of 130 healthy subjects. Venous blood was collected prior to the first chemotherapy intervention. Folate, vitamin B12 and homocysteine were measured using an automated analyzer system. Vitamin B6 was quantified using an enzyme immunoassay. Insulin and leptin were measured using immunoradiometric assay. Folic acid and vitamin B12 were significantly increased in cases compared to controls (15 ± 7 ng/ml vs. 10 ± 4 ng/ml, P=0.01; 330 ± 200 pg/ml vs. 220 ± 100 pg/ml, P=0.02) respectively. Folic acid and BMI were inversely correlated in controls (r=-0.32; P=0.05). There was no significant difference of homocysteine and vitamin B6 between cases and controls. Leptin and insulin were significantly higher in cases with BMI ≥ 27 than in controls with BMI ≥ 27 (16 ± 7 ng/ml vs. 14 ± 7 ng/ml; 32 ± 18 μIU/ml vs. 29 ± 11 μIU/ml). However, stratifying leptin and insulin by cancer stages yielded to no clear pattern. Folate may be implicated as a potential aetiological factor for colorectal cancer.


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