alexa Is Liver Disease Caused by Increased Pressure? Interstitial Pressure as a Causative Mechanism in Carcinogenesis and in the Differential Blood Supply in Liver Tumors from the Hepatic Artery
ISSN: 2167-0889

Journal of Liver
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Research Article

Is Liver Disease Caused by Increased Pressure? Interstitial Pressure as a Causative Mechanism in Carcinogenesis and in the Differential Blood Supply in Liver Tumors from the Hepatic Artery

Laurent Schwartz1 and Douglas Coldwell2*
1Ecole Polytechnique, Paris, France
2University of Louisville, Louisville, KY, USA
Corresponding Author : Douglas Coldwell, MD, Ph.D
University of Louisville
530 South Jackson St. Louisville, KY 40202, USA
Tel: 502-852-5875
E-mail: [email protected]
Received April 02, 2014; Accepted May 27, 2014; Published June 03, 2014
Citation: Schwartz L, Coldwell D (2014) Is Liver Disease Caused by Increased Pressure? Interstitial Pressure as a Causative Mechanism in Carcinogenesis and in the Differential Blood Supply in Liver Tumors from the Hepatic Artery. J Liver 3:156. doi: 10.4172/2167-0889.1000156
Copyright: © 2014 Schwartz L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: Inflammation has been noted to occur due to increased interstitial pressure. This same interstitial pressure in the liver is likely the cause of tumors receiving their blood supply primarily from the hepatic artery. Aim: The aim of the present study was to explore whether the same interstitial pressure in the liver is likely the cause of liver tumors receiving their blood supply primarily from the hepatic artery. Methods: Interstitial pressures were measured in normal and tumor parenchyma during the performance of liver biopsies. Results: The interstitial pressures in the tumors were significantly higher than the interstitial pressure in normal tissues and these pressures were high enough that only arterial blood flow could supply them. Conclusion: The interstitial pressure is the cause of the blood supply difference between normal and tumor parenchyma. This increased interstitial pressure may represent a carcinogenic agent.

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