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International Journal of Neurorehabilitation
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Research Article

Is Magnesium Sulphate more Effective than Placebo in Prevention of Seizure in Mild Preeclampsia? A Randomized Placebo-Controlled Clinical Trial

Maryam Khooshideh1, Batol Teimori2and Sama Bitarafan3*

1Department of Obstetrics and Gynecology, Arash Hospital, Tehran University of Medical Sciences, Tehran, Iran

2Department of Obstetrics and Gynecology, Ali-Ebne Abitaleb Hospital, Zahedan University of Medical Sciences, Zahedan, Iran

3Iranian Center of Neurological Research, Department of Neurology, Tehran University of Medical Sciences, Tehran, Iran

*Corresponding Author:
Sama Bitarafan
MD and PhD, Iranian Centre of Neurological Research
Department of Neurology, Tehran University of Medical Sciences
Keshavarz Blvd, Tehran, Iran
Tel: +982166948899
Fax: +982166581558
E-mail: [email protected]

Received date: February 20, 2017; Accepted date: February 26, 2017; Published date: February 28, 2017

Citation: Khooshideh M, Teimori B, Bitarafan S (2017) Is Magnesium Sulphate more Effective than Placebo in Prevention of Seizure in Mild Preeclampsia? A Randomized Placebo-Controlled Clinical Trial. Int J Neurorehabilitation 4:250. doi:10.4172/2376-0281.1000250

Copyright: © 2017 Khooshideh M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Aim: To evaluate the comparison between magnesium sulfate (MgSO4) and placebo for prevention of seizures in mild pre-eclamptic patients. (Clinical trial code: 2016052111020).

Methods and material: This double blind randomized clinical trial study was conducted on 500 patients with mild Pre-eclampsia admitted in Arash Hospital in during 2014-2016. The patients entered to equal two groups, 250 patients in group A, received MgSO4 and 250 patients in group Breceived Placebo. Primary outcome was occurrence of convulsion in mild pre-eclamptic patients. Secondary outcomes were 1 and 5 min Apgar scores in infants and number of caesarean section in each group.

Results: Mild pre-eclamptic patients in group A did not experience any convulsion; however 3 patients (1.2%) had experienced convulsion in group B. There were no significant differences in convulsion rate (p=0.08), one-min (p=0.43) and five-min Apgar score (p=0.34) between two groups but there was significant differences in numbers of caesarean section, 123 in group A (49.2%) versus 92 in group B (36.8%) between two groups (P=0.005).

Conclusion: Our results suggest that the magnesium sulfate and placebo groups are not statistically differ for prevention of seizure.

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