alexa Is MALDI-TOF Mass Spectrometry a Valuable New Tool for Microorganisms Epidemiology? | OMICS International | Abstract
ISSN: 0974-276X

Journal of Proteomics & Bioinformatics
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Review Article

Is MALDI-TOF Mass Spectrometry a Valuable New Tool for Microorganisms Epidemiology?

Silvia Vega Castaño1, Fernando Sánchez Juanes2, Laura Ferreira3, Jose Manuel González Buitrago2,4,5 and Juan Luis Muñoz Bellido2,6-8*

1Microbiology Unit, Asistencial Complex Segovia, Spain

2Institute of Biomedical Research Salamanca (IBSAL-CSIC), Spain

3MSD Sharp & Dohme GmbH, Salamanca, Spain

4Clinical Analysis, Salamanca University Welfare Complex, Spain

5Department of Biochemistry and Molecular Biology, University of Salamanca, Spain

6Microbiology Unit, Salamanca University Welfare Complex, Spain

7Departament of Biomedical Sciences and Diagnostics, University of Salamanca, Spain

8Consolidated Research Unit Infectious and Tropical Diseases, University of Salamanca, Spain

Corresponding Author:
Juan Luis Muñoz Bellido
Microbiology Unit, Salamanca University Welfare Complex
Paseo de San Vicente, 58-182, 37007 Salamanca, Spain
Tel: +34 923294400/3536
E-mail: [email protected]

Received Date: July 15, 2016; Accepted Date: September 13, 2016; Published Date: September 20, 2016

Citation: Castaño SV, Juanes FS, Ferreira L, Buitrago JMG, Bellido JLM (2016) Is MALDI-TOF Mass Spectrometry a Valuable New Tool for Microorganisms Epidemiology? J Proteomics Bioinform 9:232-237. doi: 10.4172/jpb.1000411

Copyright: © 2016 Castaño SV, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Matrix-assisted laser desorptionionization time of flight mass spectrometry (MALDI-TOF MS) is now accepted as a fast and reliable method for bacterial identification. It has been shown a very accurate method for identifying bacteria and yeast and moulds from culture, but also from blood cultures and directly from some samples, such as urine. Some authors have proposed the application of the protein profiles obtained by MALDI-TOF MS for bacterial typing and hierarchical clustering with epidemiological purposes. Here we revise and discuss the information published in the last years on the possible usefulness of MALDITOF MS for this purpose, the approaches proposed for different microorganisms and the future perspectives of this technology in the area of infectious diseases epidemiology.


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