alexa Is Oral Ibuprofen Better than Intravenous Indomethacin
ISSN: 2161-0665

Pediatrics & Therapeutics
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Research Article

Is Oral Ibuprofen Better than Intravenous Indomethacin for Medical Closure of the Patent Ductus Arteriosus in Preterm Infants?

Abdulmajid Mustafa Almawazini*, Abdulmajid Mustafa Almawazini, Ali Said Dammas Al-Ghamdi, Hamdi Hanafi Katar, Ali A Al Sharkawy, Ahmed Hussein Iqelan and Yunis Abdalla Yunis

Department of Pediatrics and Neonatology, King Fahad Hospital Albaha, Saudi Arabia

*Corresponding Author:
Abdulmajid Mustafa Almawazini
Consultant, Pediatric Cardiologist
Department of Pediatrics and Neonatology
King Fahad Hospital Albaha
P.O Box 204, Albaha 65411, Saudi Arabia
Tel: 00966508294471
E-mail: [email protected]

Received Date: December 29, 2014, Accepted January 26, 2015, Published January 28, 2015

Citation: Almawazini AM, Almawazini AM, Al-Ghamdi ASD, Katar HH, Sharkawy AAA, et al. (2015) Is Oral Ibuprofen Better than Intravenous Indomethacin for Medical Closure of the Patent Ductus Arteriosus in Preterm Infants?. Pediat Therapeut 5:231. doi:10.4172/2161-0665.1000231

Copyright: © 2015 Almawazini AM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Background: Patent Ductus Arteriosus is an open channel between the aorta and pulmonary artery. The

incidence of patent ductus arteriosus (PDA) is approximately 40% in premature infants. Objectives and Methods: To determine the effectiveness and safety of ibuprofen compared to intravenous indomethacin for closing a PDA in preterm and/or low birth weight infants. This is a case control study, retrospective review of the files of infants in control group given intravenous indomethacin, as conventional treatment: first dose of 2 mg/kg, then two doses of 0.1 mg/kg after 12 hr, 36hr respectively if the infant is either <7 days old or <1250 g, and three doses of 0.2 mg/kg if patients >7 days old or >1250 g. Infants who received oral ibuprofen in case group, as a new treatment (10 mg/kg initially followed by two doses of 5 mg/kg by interval of 24 hours) for symptomatic PDA in a neonatal intensive care unit in Pediatric and Neonatology Department, King Fahad Hospital Albaha, from January 2007 till December 2013. Only patients with isolated PDA included, while PDA associated with other congenital heart disease was excluded. Results: A total of 104 infants as control (group 1) received IV indomethacin, and 104 pts as a case (group 2) received oral ibuprofen. Among the survivors, the closure rate was 89.4% (93/104) in the indomethacin group and 91.3% (95/104) in the ibuprofen group (p =0.443). Significantly the incidence of complications was lower in the ibuprofen group: elevated serum creatinine (14.4% versus7.7%), oliguria (19.2 % versus 9.6%), and upper gastrointestinal hemorrhage (11.5 versus 4.8%); respectively (p: 0.034, p: 0.038, and p: 0.048). The incidence of necrotizing enterocolitis was higher in the indomethacin group (5.8% versus 3.9%) but not significant (p: 0.233). Conclusion: oral ibuprofen is as effective as intravenous indomethacin for closure of PDA and is associated with significantly less complications.


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