Is Oro Dental Induced Pluripotent Stem Cells (Ips) an Alternate for Dental Stem Cell Banking?Sunil PM1* and Jai Sanghar N2
- *Corresponding Author:
- Dr. Sunil PM
Professor, Department of Oral and Maxillofacial Pathology
Rajah Muthiah Dental College and Hospital
Annamalai Nagar, Annamalai University
Chidambaram, Tamil Nadu–608002, India
E-mail: [email protected]
Received date: December 19, 2012; Accepted date: January 17, 2013; Published date: January 19, 2013
Citation: Sunil PM, Jai Sanghar N (2013) Is Oro Dental Induced Pluripotent Stem Cells (Ips) an Alternate for Dental Stem Cell Banking? J Cell Sci Ther 3:136. doi:10.4172/2157-7013.1000136
Copyright: © 2013 Sunil PM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Dental stem cells, a new area of stem cell research is gaining popularity due to its easy accessibility and plasticity. On other hand iPSc (induced pluripotent stem cells) which can be generated from many tissues in the body has attracted many researchers towards it. This brief communication comparatively reviews the advantages and disadvantages of Dental Stem Cell Banking (DSCB) with iPSc. Similar to cord cell banking DSCB can also serve as source for stem cells. Reprogramming the cells by transfecting with specific transcriptional factors helps in deriving the iPS cells. Recent studies have shown dental pulp cells can be efficiently reprogrammed than dermal fibroblasts in generating iPSc. Other than dental pulp, iPS cells were also made from other tissues of oro-dental region which includes gingival, buccal mucosa and periodontal ligament. The disadvantages of iPS cells like, tumor and teratoma formation can be avoided by newer non integration techniques. It can be concluded that though iPSc cannot replace DSCB in the present scenario but, in future it has paramount role in regeneration after prospective research.