Is Osteoarthritis of the Knee Hereditary? A Review of the Literature
Clement ND *
Speciality Trainee Trauma and Orthopaedics, United Kingdom
- *Corresponding Author:
- Clement ND
Speciality Trainee Trauma and Orthopaedics
Royal Infirmary of Edinburgh, Little France
EH16 4SA, United Kingdom
E-mail: [email protected]
Received Date: March 22, 2013; Accepted Date: April 22, 2013; Published Date: April 25, 2013
Citation: Clement ND (2013) Is Osteoarthritis of the Knee Hereditary? A Review of the Literature. Hereditary Genetics S1:004. doi: 10.4172/2161-1041.S1-004
Copyright: © 2013 Clement ND. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Osteoarthritis (OA) of the knee joint is a common cause of disability. This review presents the current evidence and knowledge regarding the genetic inheritability of OA of the knee, and a contemporary hypothesis for progression of the disease. The current evidence would suggest there is a hereditary predisposition to OA of the knee. However, this would seem to be multifactorial and the development of OA in the knee may depend upon multiple genetic factors, not only of those relating to cartilage degeneration but also of those relating to the morphology of the knee joint, both of these factors seem to be influenced by similar genes. Knowledge of these genes that affect the initiation and/ or progression of knee OA are important for development of new treatment options at an early stage of the disease preventing future physical disability.