Is There A Relationship Between Visfatin Level and Type 2 Diabetes Mellitus In Obese And Non Obese Patients?Eid M El-Shafey1*, Gamal F El-Naggar1, Mohamed M Al-Bedewy2 and Hesham El-Sorogy3
- Corresponding Author:
- Eid M El-Shafey
Faculty of Medicine, Internal Medicine Department, Nephrology Division
Tanta University, Tanta, Egypt
E-mail: [email protected]
Received Date: May 29, 2012; Accepted Date: July 07, 2012; Published Date: July 13, 2012
Citation: El-Shafey EM, El-Naggar GF, Al-Bedewy MM, El-Sorogy H (2012) Is There A Relationship Between Visfatin Level And Type 2 Diabetes Mellitus In Obese and Non Obese Patients? J Diabetes Metab S11:001. doi:10.4172/2155-6156.S11-001
Copyright: © 2012 El-Shafey EM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: Visfatin is a newly discovered cytokine that is highly expressed in visceral fat with a direct relationship to type 2 diabetes mellitus (T2DM). The present study was conducted to demonstrate the relationship between plasma visfatin level and T2DM whether in obese or non obese patients.
Subjects and methods: This prospective study was carried out on 74 subjects divided into 4 groups. Group I: Twenty obese non diabetic patients, Group II: Twenty obese diabetic patients, Group III: Twenty non obese diabetic patients and Group IV: Fourteen age and gender matched apparently healthy subjects to serve as controls. All patients and controls were subjected to full history taking, complete clinical examination, routine laboratory investigations, fasting serum insulin, homeostasis model assessment of insulin resistance (HOMAIR) and serum visfatin level.
Results: Serum visfatin level was significantly increased in the obese subjects and in the diabetics with the highest rise in the obese diabetics suggesting that serum visfatin level has a link between obesity and T2DM. Also, there was a significant positive correlation between serum visfatin level and body mass index (BMI), serum insulin & HOMAIR.
Conclusion: There may be a possible role of visfatin in the Pathophysiology of insulin resistance, T2DM and obesity.