Is Valacyclovir a Mood Stabilizer?
Theodore A Henderson*
President, The Synaptic Space, USA
- *Corresponding Author:
- Theodore A Henderson, MD, PhD
The Synaptic Space, 3979 E. Arapahoe Road
Suite 200, Centennial CO 80122, USA
Tel: 720-493-1101; 303-915-4386
E-mail: [email protected]
Received date August 21, 2013; Accepted date October 10, 2013; Published date October 16, 2013
Citation: Henderson TA (2013) Is Valacyclovir a Mood Stabilizer? Autism 3:118. doi:10.4172/2165-7890.1000118
Copyright: © 2013 Henderson TA. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Growing evidence indicates the role of viral agents in neuropsychiatric conditions, such as chronic fatigue syndrome (CFS), Alzheimer’s disease, and possibly autism. This case report describes a patient who was afflicted with treatment-resistant childhood bipolar disorder, who also had features associated with attention deficit hyperactivity disorder and autism spectrum disorder. After failing multiple regimens for mood stabilization (anticonvulsants, lithium, neuroleptics), a trial of valacyclovir was initiated. The decision to use an antiviral agent was based on the patient’s laboratory data and the marked treatment response of the patient’s sibling, who manifested symptoms of depression and CFS. The patient in this report showed a dramatic improvement in his volatile mood, irritability, concentration, social reciprocity, and overall personality. He was maintained on valacyclovir at 1000 mg BID, while the doses of the mood stabilizing agents and stimulants were reduced by as much as 50%. After 37 months of ongoing valacyclovir treatment, the patient continues to make improvements and is being mainstreamed in school. The case illustrates a potential role of viruses in neuropsychiatric and psychiatric disorders and the potential benefit of antiviral therapy in treatment-refractory cases.