alexa Isolation, Characterisation and Antifungal Activity of β-Lapachone from Tecomaria capensis (Thunb.) Spach Leaves | OMICS International | Abstract
ISSN: 2167-0412

Medicinal & Aromatic Plants
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Research Article

Isolation, Characterisation and Antifungal Activity of β-Lapachone from Tecomaria capensis (Thunb.) Spach Leaves

Karthikeyan R1*, Sai Koushik O1 and Kumar PV2
1Vignan Pharmacy College, Vadlamudi, Guntur-522 213, Andhra Pradesh, India
2Faulty of Pharmaceutical Sciences, UCSI University, Kualalampur, Malaysia
*Corresponding Author : Karthikeyan R
Vignan Pharmacy College
Vadlamudi, Guntur-522 213
Andhra Pradesh, India
Tel: 91-9966847127
E-mail: [email protected]
Received January 27, 2016; Accepted February 27, 2016; Published February 29, 2016
Citation: Karthikeyan R, Sai Koushik O, Kumar PV (2016) Isolation, Characterisation and Antifungal Activity of β-Lapachone from Tecomaria capensis (Thunb.) Spach Leaves Med Aromat Plants 5:239. doi:10.4172/2167-0412.1000239
Copyright: © 2016 Karthikeyan R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

β-Lapachone (3, 4-dihydro-2,2-dimethyl-2H-naphthol [1,2-b] pyran-5,6-dione), was originally isolated from the lapacho tree (Tabebuia avellanedae) of South America. It is a lipophilic ortho-naphthoquinone. β-Lapachone has antimicrobial, antifungal, antiviral antitumor and anti-trypanosomal activities. In a number of tumors (e.g., breast, colon, lung, and pancreatic cancers) with high NAD (P) H expression levels of: quinone oxidoreductase (NQO1), β-lapachone activates a novel apoptotic response. β-Lapachoneis a major constituent of the species Tecomaria capensis (Thunb.) Spach. On silica gel GF254 TLC plates and the chromate plate analytical thin layer chromatography was accomplished. It was developed withToluene: Ethyl acetate (7:3 v/v) as mobile phase. In this study isolation of β-Lapachone was achieved by preparative TLC. The compound thus isolated was characterised by Mass, H1 NMR and FT-IR spectral analysis. Mass spectral data shows molecular ion peak of m/z=242. Antifungal activity was measured against Candida albicans and Aspergillus nigrus fromethyl acetate extracts of selected species.

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