alexa Isolation of Three Bioactive Phenantroindolizidine Alkaloids from the Fruit Latex of Ficus botryocarpa Miq
ISSN: 2329-6836

Natural Products Chemistry & Research
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Research Article

Isolation of Three Bioactive Phenantroindolizidine Alkaloids from the Fruit Latex of Ficus botryocarpa Miq

Jayson Wau1*, David Timi1, Anthony Harakuwe1, Bruce Bowden2, Cherie Motti3, Harry Sakulas4 and Rag Gubag-Sipou1
1Department of Applied Sciences, PNG University of Technology, PMB, Lae, Papua New Guinea
2School of Pharmacy and Molecular Science, James Cook University, Molecular Science Building DB21, Townsville Campus, Australia
3Australian Institute of Marine Science, PMB No 3, Townsville Mail Center, Q 4810, Australia
4Environment Research Management Centre, PNG University of Technology, PMB, Lae, Papua New Guinea
Corresponding Author : Jayson Wau
Department of Applied Sciences, PNG University of Technology
PMB, Lae, Papua New Guinea 675
Tel: +675- 4734551
E-mail: [email protected]
Received: November 04, 2015; Accepted: November 22, 2015; Published: November 24, 2015
Citation: Wau J, Timi D, Harakuwe A, Bowden B, Motti C, et al. (2015) Isolation of Three Bioactive Phenantroindolizidine Alkaloids from the Fruit Latex of Ficus botryocarpa Miq. Nat Prod Chem Res 3:197. doi:10.4172/2329-6836.1000197
Copyright: © 2015 Wau J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Latex of F. botryocarpa fruit is applied on skin infections in Papua New Guinea ethnotherapeutic practices. Systematic bioassay guided separation and isolation of subsequent fractions of latex extracts resulted in three bioactive fractions. Structures were determined by physical (M.pt and Rf values) and spectroscopic (1D-1H NMR, 2D-HSQC NMR, 2D-HMBC NMR) and MS ESI-POS. The two methylene protons (2H-1) and 2H-3) resonate as triplets at δ 3.59 and δ 4.99 respectively. Electron dense δ 4.99 (2H-3) on (C-3) depicts the strong electron withdrawing component, quaternary nitrogen (=N=+). Protons resonating at δ 3.88 and δ3.89 are singlets depicting two methoxy groups. Both δ 3.88 and δ 3.89 are para-aryls substituents. All isolates, (1), (2) and (3) were identified to be ficuseptine. 2D-NMR and MS of (2) found it to be ficuseptine chloride “2, 3-dihydro-6, 8-bis (4-methoxyphenyl)-1,2,3-trihydroindolizidinium chloride”. The counter ions were not established and provide promising lead for further investigation.

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