alexa Isoniazid Preventive Therapy: Level of Adherence and Its Determinant Factors among HIV Positive Patients in Adama Hospital Medical College, Oromia, Ethiopia, 2016 | Abstract
ISSN: 2329-8731

Journal of Infectious Diseases & Preventive Medicine
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Research Article

Isoniazid Preventive Therapy: Level of Adherence and Its Determinant Factors among HIV Positive Patients in Adama Hospital Medical College, Oromia, Ethiopia, 2016

Elias Abdulalim1, Sileshi Garuma2, Bekele Dibaba1, and Tolossa E Chaka3*

1Department of Public Health, College of Health Sciences, Arsi University, Ethiopia

2Department of Public Health, Adama Hospital Medical College, Ethiopia

3Department of Paediatrics and Child Health, Adama Hospital Medical College, Ethiopia

Corresponding Author:
Tolossa Eticha Chaka
Department of Paediatrics and Child Health
Adama Hospital Medical College, Ethiopia
Tel: +251911413135
E-mail: [email protected]

Received date: January 31, 2017; Accepted date: February 20, 2017; Published date: February 27, 2017

Citation: Abdulalim E, Garuma S, Dibaba B, Chaka TE (2017) Isoniazid Preventive Therapy: Level of Adherence and Its Determinant Factors among HIV Positive Patients in Adama Hospital Medical College, Oromia, Ethiopia, 2016. J Infect Dis Preve Med 5: 154. doi: 10.4172/2329-8731.1000154

Copyright: © 2017 Abdulalim E, et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Background: Tuberculosis is an airborne disease caused by Mycobacterium Tuberculosis (M.TB). Mycobacterium bacilli in the body will get destroyed or presented to white blood cell that could trigger immune response and ultimately establishes latent tuberculosis infection. Isoniazid preventive therapy (IPT) hinders the development of active TB in patients with latent TB infection. All HIV positive patients without contraindications are eligible for IPT.

Methods: A facility based cross-sectional study was conducted to assess the level of adherence to IPT and its determinant factors among HIV positive patients at Adama Hospital Medical College ART clinic. One hundred sixty eight patients who were ≥ 18 years of age and who took IPT at least for two months were consecutively interviewed. SPSS version 21 was used for data entry, cleaning and analysis. Descriptive and analytic statistics were utilized. Crude and adjusted odds ratio (COR & AOR respectively) with 95% confidence interval (CI) was used to interpret the findings.

Result: A total of 168 respondents were included in the study. The seven day self-reported adherence rate was 68.5%. The average number of doses missed in the past seven days prior to the study was 0.8 doses per day. Forgetfulness (59%, N=49), being away from home (25.3%, N=21) & being busy (15.7%, N=13) were the most common reasons for ever missing pills since the start isoniazid. Abdominal side effects [AOR 3.76 (1.38, 10.26)], unclear information from health care providers [AOR 3.59 (1.63, 7.93)], not using memory aiding tools for dose schedule [AOR, 2.15 (1.03,4.49)] and perceived lack of confidentiality [AOR 7.01 (2.71,18.12)] were the factors associated with the poor adherence of IPT.

Conclusion: IPT adherence rate is poor. Clear and targeted health education should be given by service providers. Medication side effects should be addressed promptly.


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