alexa Issues in Propofol Sedation for Pediatric Patients Usin
ISSN: 2161-0665

Pediatrics & Therapeutics
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Research Article

Issues in Propofol Sedation for Pediatric Patients Using Target Control Infusion (TCI): Safety in Children 1-3 Years Old Versus Children Older than 3 Years of Age

Tak Kyu Oh1, Kyungho Kwon1, Boram Park2and Woosik Eom1*

1Department of Anaesthesiology and Pain Medicine, National Cancer Centre, Republic of Korea

2Biometric Research Branch, Research Institute and Hospital, National Cancer Centre, Republic of Korea

*Corresponding Author:
Woosik Eom
Department of Anesthesiology and Pain Medicine
National Cancer Center, 323, Ilsan-ro
Ilsandong-gu, Goyang-si
Gyeonggi-do 10408, Republic of Korea
Tel: +82-031-920-1703
Fax: +82-031-920-1465
E-mail: [email protected]

Received date April 07, 2016; Accepted date May 26, 2016; Published date May 30, 2016

Citation: Oh TK, Kwon K, Park B, Eom W (2016) Issues in Propofol Sedation for Pediatric Patients Using Target Control Infusion (TCI): Safety in Children 1-3 Years Old Versus Children Older than 3 Years of Age. Pediatr Ther 6:291. doi:10.4172/2161-0665.1000291

Copyright: ©2016 Oh TK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.



Purpose: Appropriate sedation is required when performing proton radiation therapy on pediatric patients. A target-controlled infusion (TCI) of propofol has recently been used for this purpose. However, there may be safety issues with the use of TCI in pediatric patients, as the initial bolus dose might be excessive for younger patients. To compare the safety and the incidence of adverse events between patients under and over 3 years of age undergoing sedation with a TCI (Paedfusor) model.

Methods: We performed a retrospective observational study by analyzing the medical records of patients who underwent a computer tomography simulation prior to beginning proton radiation therapy between January 2013 and December 2014. Patients were divided into those 1-3 years of age and those > 3 years of age. The incidence of adverse events was tabulated.

Results: Fifty-two patients-16 patients 1-3 years of age and 40 patients > 3 years of age-were included in the study. The adverse event incidence was the primary outcome. There was no statistically significant difference in desaturation (p = 0.231), nasopharyngeal airway insertion (p = 0.366), bradycardia (p = 1.000), and hypotension (p = 0.578). Additionally, there was no significant difference in sedation time, recovery time, propofol dose, and target concentration for induction or maintenance of anesthesia.

Conclusions: The use of propofol TCI for the induction and maintenance of sedation did not show an increased risk of adverse events in pediatric patients 1-3 years of age versus patients > 3 years of age.


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