JC Polyomavirus Infections in Transplant Patients
- *Corresponding Author:
- Mariano Ferraresso
Department of General and Vascular Surgery
St. Joseph Hospital-IRCCS-Multimedia
Via San Vittore 12, 20122 Milan, Italy
Fax: +39 0250320394
Tel: +39 0250320382
E-mail: [email protected]
Received Date: October 01, 2012; Accepted Date: October 04, 2012; Published Date: October 12, 2012
Citation: Delbue S, Ferraresso M (2012) JC Polyomavirus Infections in Transplant Patients. J Transplant Technol Res 2: e114. doi: 10.4172/2161-0991.1000e114
Copyright: © 2012 Delbue S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The polyomavirus JC virus (JCV) is a small nonenveloped DNA virus that asymptomatically infects about 80% of healthy adults and establishes latency in the kidney tissue. In case of immunodeficient hosts, JCV can lytically infect the oligodendrocytes, causing a fatal demyelinating disease, known as Progressive Multifocal Leukoencephalopathy (PML). Although the reactivation of another human polyomavirus, BK Virus (BKV), is relatively common and its association with the Polyomavirus Associated Nephropathy (PVAN) following renal transplantation is assessed, JCV replication and its impact on graft function and survival is less well studied. In addition, none of the performed studies
ruled out the hypothesis that JCV could be associated with certain post-transplantation clinical syndromes. Thus, monitoring of Polyomaviruses infection, especially during the first 24 months post-transplantation, is recommended.