alexa Ketamine: An Update for Its Use in Complex Regional Pain Syndrome and Major Depressive Disorder
ISSN: 2161-1459

Journal of Clinical & Experimental Pharmacology
Open Access

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Ketamine: An Update for Its Use in Complex Regional Pain Syndrome and Major Depressive Disorder

William E Bentley*, Michael Sabia, Michael E Goldberg and Irving W Wainer

Cooper University Hospital, Camden, New Jersey, United States of America

*Corresponding Author:
Bentley WE
Cooper University Hospital, Camden, New Jersey
United States of America, Hammonton, NJ 08037
Tel: 732-642-6142
E-mail: [email protected]

Received date: January 26, 2015; Accepted date: February 26, 2015; Published date: March 02, 2015

Citation: Bentley WE, Sabia M, Goldberg ME, Wainer IW (2015) Ketamine: An Update for Its Use in Complex Regional Pain Syndrome and Major Depressive Disorder. Clin Exp Pharmacol 5:169. doi: 10.4172/2161-1459.1000169

Copyright: © 2015 Bentley WE, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Abstract In recent years, there has been significant research in regard to the efficacy of ketamine in regards to treating Complex Regional Pain Syndrome (CRPS) and Major Depressive Disorder (MDD). Many patients have had substantial symptomatic relief; however, not all patients have had positive results. This has prompted current research with evidence to suggest certain biomarkers exist that would infer which patients will/will not respond to ketamine treatment. Current biomarkers of interest include D-Serine (D-Ser) and magnesium, which will be discussed. Whether or not D-Ser and/or magnesium levels should be checked and possibly dictate therapy is an area of future research. It is also possible that downstream metabolites of ketamine are the key to successful therapy


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