Ketogenic Diet For Refractory Epilepsy In Children- An Institutional Experience
- *Corresponding Author:
- Nélia Ferraria
Centro de Desenvolvimento da CriançaTorrado da Silva
Hospital Garcia de Orta Avenida Torrado da Silva
Pragal, 2801-951 Almada, Portugal
Tel: +351 96 551 89 23
Fax: + 351 21 272 72 77
Received Date: July 10, 2013; Accepted Date: July 28, 2013; Published Date: July 30, 2013
Citation: Ferraria N, Mendes P, Oliveira F, Martins C, Fonseca MJ, et al. (2013) Ketogenic Diet for Refractory Epilepsy in Children-An Institutional Experience. Pediat Therapeut 3:162. doi: 10.4172/2161-0665.1000162
Copyright: © 2013 Ferraria N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Introduction: Ketogenic diet consists in a adequate protein diet (1 qram/kg), low in carbohydrates and rich in lipids, which induces a prolonged state of ketosis that modifies the cerebral energetic metabolism. This study aims to characterize the children with refractory epilepsy treated with ketogenic diet, enrolled in a Child Development Center in Portugal. It intends to evaluate the efficacy and tolerability of the diet and to identify in which epilepsy syndromes and etiologies the diet is effective. Methods: Retrospective analysis of the cases of refractory epilepsy treated with ketogenic diet. Results: Sixteen children were included, eleven boys. The mean age of seizures onset was 13,9 months (0-72 months) and of ketogenic diet onset was 4,4 years (5 months-16 years). At the end of the first month, 62,5% had a seizure reduction of more than 50%. The efficacy reached 43,8% at the end of third month and 31,3% at the end of the sixth month. In 31,3% there was a reduction of the number of anti-epileptic drugs and 56,3% had an improvement in the behavior/ cognition. The diet was more effective in infantile spasms, Lennox-Gastaut and Dravet syndromes and genetic and structural epilepsies, particularly in malformations of the cortical development. The mean time to a clinical response was 1,4 months. The diet had a good tolerability, with side effects only in 31,2%, none with clinical severity. Conclusion: In this study, ketogenic diet has proven to be safe and effective and should be considered in children with severe and refractory epilepsies.