alexa Ketogenic Diet in Advanced Cancer: A Pilot Feasibility and Safety Trial in the Veterans Affairs Cancer Patient Population
ISSN: 2167-0870

Journal of Clinical Trials
Open Access

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Protocol

Ketogenic Diet in Advanced Cancer: A Pilot Feasibility and Safety Trial in the Veterans Affairs Cancer Patient Population

Jocelyn Tan-Shalaby1* and Thomas Seyfried2
1Veteran Affairs Pittsburgh Healthcare System, Section of Hematology Oncology, USA
2Biology Department, Boston College, 140 Commonwealth Avenue, Chestnut Hill, MA 02467, USA
Corresponding Author : Jocelyn Tan-Shalaby
Veteran Affairs Pittsburgh Healthcare System
Section of Hematology Oncology
Clinical Assistant Professor
University of Pittsburgh School of Medicine, USA
E-mail: [email protected]
Received October 08, 2013; Accepted November 27, 2013; Published November 29, 2013
Citation: Tan-Shalaby J, Seyfried T (2013) Ketogenic Diet in Advanced Cancer: A Pilot Feasibility and Safety Trial in the Veterans Affairs Cancer Patient Population. J Clin Trials 3:149. doi:10.4172/2167-0870.1000149
Copyright: © 2013 Tan-Shalaby J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

In their natural state within the body, normal cells use cellular respiration as their main source of ATP and energy. Carbohydrate deprived cells easily depend on the resulting ketone bodies for an alternative energy source. This natural evolutionary adaptation to starvation allows for survival of normal cells during times of fasting or famine. Cancer cells in contrast are defective in this respect, lacking the ability to utilize ketone bodies for energy and depend heavily on glycolysis for survival. The pancreas senses increased carbohydrate intake resulting in increased insulin secretion. Normal growth throughout the body depends on insulin, which by itself is also a potent growth factor which binds to cell membrane insulin receptors and stimulates mitosis via signal transduction and DNA synthesis, resulting in less
apoptosis or tumor cell death. Consequentially, carbohydrate restriction will increase tumor cell destruction. We are conducting a pilot study to examine the safety and tolerability of the ketogenic diet KD in patients with advanced cancer within the Veteran Affairs Pittsburgh Healthcare System (VAPHS) oncology patient population.

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