alexa Ki 67 as Prognostic Factor in Surgically Resected Pancreatic Ductal Adenocarcinoma | OMICS International| Abstract
[Jurnalul de Chirurgie]
ISSN: 1584-9341

Journal of Surgery
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  • Research Article   
  • Surgery 2019, Vol 15(1): 7

Ki 67 as Prognostic Factor in Surgically Resected Pancreatic Ductal Adenocarcinoma

Florina-Delia Andriesi-Rusu, Ana-Maria Trofin, Irene Cianga-Spiridon*, Nutu Vlad, Alin Vasilescu, Eugen Târcoveanu and Cristian Lupașcu
First Surgical Unit, “St. Spiridon” Hospital, University of Medicine and Pharmacy “Gr.T. Popa” Iasi, Romania
*Corresponding Author : Irene Cianga-Spiridon, MD, First Surgical Unit, “St. Spiridon” Emergency University Hospital Iasi, Independentei Street, No 1, 700544, Iasi, Romania, Tel: +40(0)741024493, Fax: +40(0)232218272, Email: [email protected]

Received Date: Apr 09, 2019 / Accepted Date: Apr 29, 2019 / Published Date: May 06, 2019

Abstract

Background: Pancreatic ductal adenocarcinoma is one of the most aggressive neoplasms, with a poor prognostic and overall survival, most of the patients (over 80%) being diagnosed in advanced stages of the disease, either with distant metastasis or with the locally unresectable tumor. The Ki-67 antigen is a nuclear antigen expressed in all cellular phases (except for the G0 phase) and a high Ki-67 index can be correlated with a recurrence rate of tumor and survival.
Aim: The aim of our study was to demonstrate if the Ki-67 index can be used as a negative prognostic factor for survival.
Methods: We reviewed retrospectively all patients with pancreatic ductal adenocarcinoma (confirmed histologically) and were selected only those with resectable tumors (19.5%). For these patients, immunoreactivity for Ki-67 was evaluated according to the percentage of positive tumor nuclei. The survival was calculated from the data of surgery to a patient’s death.
Results: 19.5% of patients were diagnosed with surgically resectable tumors, with a mean tumor’s size of 3.3 cm. The overall survival rate at 2 years was 21.15%. The patients with a Ki-67 index over 80% had a significantly lower average survival than the other patients.
Conclusions: The immunohistochemistry staining for Ki-67 can be applied as a prognostic marker for survival in resectable ductal pancreatic adenocarcinoma.

Keywords: Ki-67; Pancreatic ductal adenocarcinoma; Prognostic factors; Survival

Citation: Andriesi-Rusu F, Trofin A, Cianga-Spiridon I, Vlad N, Vasilescu A, et al. Ki 67 as Prognostic Factor in Surgically Resected Pancreatic Ductal Adenocarcinoma. Journal of Surgery [Jurnalul de chirurgie]. 2019; 15(1): 01-05.

Copyright: © 2019 Andriesi-Rusu F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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