Ki 67 as Prognostic Factor in Surgically Resected Pancreatic Ductal Adenocarcinoma
Received Date: Apr 09, 2019 / Accepted Date: Apr 29, 2019 / Published Date: May 06, 2019
Background: Pancreatic ductal adenocarcinoma is one of the most aggressive neoplasms, with a poor prognostic and overall survival, most of the patients (over 80%) being diagnosed in advanced stages of the disease, either with distant metastasis or with the locally unresectable tumor. The Ki-67 antigen is a nuclear antigen expressed in all cellular phases (except for the G0 phase) and a high Ki-67 index can be correlated with a recurrence rate of tumor and survival.
Aim: The aim of our study was to demonstrate if the Ki-67 index can be used as a negative prognostic factor for survival.
Methods: We reviewed retrospectively all patients with pancreatic ductal adenocarcinoma (confirmed histologically) and were selected only those with resectable tumors (19.5%). For these patients, immunoreactivity for Ki-67 was evaluated according to the percentage of positive tumor nuclei. The survival was calculated from the data of surgery to a patient’s death.
Results: 19.5% of patients were diagnosed with surgically resectable tumors, with a mean tumor’s size of 3.3 cm. The overall survival rate at 2 years was 21.15%. The patients with a Ki-67 index over 80% had a significantly lower average survival than the other patients.
Conclusions: The immunohistochemistry staining for Ki-67 can be applied as a prognostic marker for survival in resectable ductal pancreatic adenocarcinoma.
Keywords: Ki-67; Pancreatic ductal adenocarcinoma; Prognostic factors; Survival
Citation: Andriesi-Rusu F, Trofin A, Cianga-Spiridon I, Vlad N, Vasilescu A, et al. Ki 67 as Prognostic Factor in Surgically Resected Pancreatic Ductal Adenocarcinoma. Journal of Surgery [Jurnalul de chirurgie]. 2019; 15(1): 01-05.
Copyright: © 2019 Andriesi-Rusu F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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