alexa Kimura's Disease: Uncommon Cause of Proptosis

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Case Report

Kimura's Disease: Uncommon Cause of Proptosis

Mohd Syafiq bin Azman1*, Shawarinin binti Jusoh2, Akmal Haliza binti Zamli2 and Azlina binti Abd Rahman2

1Department of Medicine Jabatan Oftalmologi, Hospital Tengku Ampuan Afzan, Jalan Tanah Putih, 25100 Kuantan, Pahang, Malaysia

2Department of Medicine, Universiti Kebangsaan, Malaysia

*Corresponding Author:
Mohd Syafiq bin Azman
Department of Medicine Jabatan Oftalmologi
Hospital Tengku Ampuan Afzan
Jalan Tanah Putih, 25100 Kuantan, Pahang, Malaysia
Tel: +60173129970
E-mail: [email protected]

Received Date: March 08, 2017; Accepted Date: March 16, 2017; Published Date: March 19, 2017

Citation: Azman MSB, Jusoh SB, Zamli AHB, Rahman ABA (2017) Kimura's Disease: Uncommon Cause of Proptosis. Med Rep Case Stud 2: 132. doi:10.4172/2572-5130.1000132

Copyright: © 2016 Azman MSB, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Purpose: To describe a case of inferior orbital mass with generalized lymphadenopathy and histopathological examination proven Kimura’s disease. Methodology: Case report Findings: A 17 year-old Malay man with no previous illness. Presented with two months history of progressive proptosis of the right eye (RE). Upon presentation vision was 6/7.5 RE and left eye (LE) 6/6. Ocular examination revealed RE proptosis with restricted extraocular muscle movement and optic disc swelling. Systemic examination noted multiple lymphadenopathy over cubital fossa and inguinal region. Blood investigation showed peripheral eosinophilia. CT brain and orbit revealed RE inferior orbital mass compressing the optic nerve. Subsequently RE orbital mass incisional biopsy and inguinal node excisional biopsy was done. The later showed typical features of Kimura’s disease with diffuse eosinophils infiltration within the germinal centres of the lymphoid nodule. He was started on tapering dose of oral corticosteroids and responded well evidenced by reducing RE proptosis. Conclusion: This case demonstrates that proptosis with lymphadenopathy does not always imply lymphoma but may have a benign pathogenesis such as Orbital Kimura’s disease. Therefore it should be considered in the differential diagnosis of orbital lesions occurring in adults. Accurate diagnosis in biopsies is also crucial to avoid unnecessary radical surgery.


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