alexa Klinefelters Syndrome with a Cutaneous Manifestation of Lower Limb Ulceration | OMICS International
ISSN: 2155-9554

Journal of Clinical & Experimental Dermatology Research
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Case Report

Klinefelters Syndrome with a Cutaneous Manifestation of Lower Limb Ulceration

Jacintha Martis*, Ashwini Babu, Sudeep D and John Joseph S Martis

Father Muller Medical College, Mangalore, Karnataka, India

*Corresponding Author:
Jacintha Martis MD
Department of Dermatology, Father Muller Medical College
Mangalore, Karnataka, India
Tel: +91-9845148112
Email: [email protected]

Received date: March 06, 2015; Accepted date: April 30, 2015; Published date: May 04, 2015

Citation: Martis J, Babu A, Sudeep D, Joseph J, Martis JJS (2015) Klinefelter’s Syndrome with a Cutaneous Manifestation of Lower Limb Ulceration . J Clin Exp Dermatol Res 6:278. doi: 10.4172/2155-9554.1000278

Copyright: © 2015 Martis J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Klinefelter’s syndrome (KS) is considered the most common type of male hypogonadism. The majority (80-90%) of patients are seen to have 47 XXY karyotype. Leg ulceration has been described as a complication of Klinefelter’s syndrome. A young 21 year old male presented with a non-healing ulcer of the lower extremity of three years duration. Doppler studies and autoimmune workup was negative. However, clinical and further laboratory findings were consistent with Klinefelter’s Syndrome. This case report highlights the importance of screening for chromosomal abnormalities besides evaluating for peripheral vascular disease, venous stasis and diabetes mellitus especially in a young male patient with chronic leg ulceration.

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