alexa Laboratory Monitoring of Individuals with Subclinical C
ISSN: 2155-9554

Journal of Clinical & Experimental Dermatology Research
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Research Article

Laboratory Monitoring of Individuals with Subclinical Cutaneous Leishmaniasis Infections in Southern Brazil

Sandra Mara Alessi Aristides1*, Marcos Vinícius Zandonadi Bernal1, Herintha Coeto Neitzke-Abreu2,3, Nádia Baggio Ratti1, Maria Valdrinez Campana Lonardoni1 and Thaís Gomes Verzignassi Silveira1

1Department of Clinical Analysis and Biomedicine, Universidade Estadual de Maringá, Maringá, Brazil

2Health Sciences Postgraduate Program, Universidade Estadual de Maringá, Maringá, Brazil

3Faculty of Health Sciences, Universidade Federal da Grande Dourados, Dourados, Brazil

*Corresponding Author:
Dr. Sandra Mara Alessi Aristides
Universidade Estadual de Maringá, Avenue Colombo
5790, Maringá, State of Paraná, Brazil, 87020-900
Tel: +55 44 3011-4878
Fax: +55 44 3011-4860
E-mail: [email protected]

Received date: June 02, 2014; Accepted date: June 28, 2014; Published date: July 05, 2014

Citation: Aristides SMA, Bernal MVZ, Neitzke-Abreu HC, Ratti NB, Lonardoni MVC, et al. (2014) Laboratory Monitoring of Individuals with Subclinical Cutaneous Leishmaniasis Infections in Southern Brazil. J Clin Exp Dermatol Res 5:224. doi: 10.4172/2155-9554.1000224

Copyright: © 2014, Aristides et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Background: Cutaneous leishmaniasis (CL) has a high incidence worldwide. Most individuals with CL develop the cutaneous form, but subclinical infections may occur. Objective: The present study used different laboratory methods [polymerase chain reaction (PCR), indirect immunofluorescence (IIF) and enzyme reaction immunoassay (ELISA)] to investigate the incidence, and monitor individuals with subclinical infections.

Patients and methods: The six individuals with subclinical infections included residents of a CL endemic area. Collections of biological material were carried out for nearly three years.

Results: Two of these individuals were positive for Leishmania, one of them by PCR and the other by PCR, IIF and ELISA after previous negative results.

Conclusion: The presence of a subclinical infection suggests the development of an appropriate immune response that can control replication of the parasite and maintain the integrity of the tissue. Individuals with subclinical infections must be correctly diagnosed and monitored using different methods, because of the possibility of the development of the mucosal form, and may serve as reservoirs for the insect vector.


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