Lactic Dehydrogenase in Umbilical Cord Blood in Healthy Infants after Different Modes of Delivery
|Eva Wiberg-Itzel1*, Hampus Josephson1, Nana Wiberg2, Linus Olson3, Birger Winbladh4 and Mathias Karlsson4,5|
|1Department of Clinical Science and Education, Section of Obstetrics and Gynecology, Karolinska Institute, Soder Hospital, Sweden|
|2Department of Gynecology and Obstetrics, Herlev Hospital, Copenhagen Denmark|
|3Department of Women’s and Children’s Health, Karolinska Institute, Sweden|
|4Department of Clinical Sciences and Education, Sachs Children’s Hospital, Karolinska Institute, Sweden|
|5Department of Clinical Chemistry, Central Hospital, Karlstad, Sweden|
|Corresponding Author :||Eva Wiberg-Itzel
Department of Obstetrics and Gynecology
Soder Hospital of Stockholm, 118 83 Stockholm, Sweden
Tel: +46 86163768
E-mail: [email protected] itzel.e
|Received: October 25, 2015 Accepted: November 16, 2015; Published: November 26, 2015|
|Citation: Wiberg-Itzel E, Josephson H, Wiberg N, Olson L, Winbladh B, et al. (2015) Lactic Dehydrogenase in Umbilical Cord Blood in Healthy Infants after Different Modes of Delivery. J Neonatal Biol 4:204. doi:10.4172/2167-0897.1000204|
|Copyright: © 2015 Wiberg-Itzel E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
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Background: LDH may be a valuable marker for some of the most important diseases in newborns, and umbilical cord blood is a non-invasive and easy way to obtain blood for analysis. Aims of this study were to define interval for LDH in arterial and venous cord blood at delivery in truly healthy newborns.
Method: a prospective observational study was performed at Soder Hospital, Stockholm, Sweden during 2011-2012. Umbilical cord blood was collected at delivery, and value of LDH was analysed in 549 healthy infants >37 weeks of gestation, born after an uncomplicated pregnancy from a healthy mother.
Results: The 2.5th and 97.5th percentile for arterial LDH was 162-612 u/L and 252-636 u/L for venous LDH. Instrumental delivery and acute caesarian section showed significantly higher intervals and elective caesarian section significantly lower than vaginal delivery. Haemolysis (>0.3g/l) disqualified a 13-41% of the samples. Conclusion: Reported LDH levels are in accordance with earlier studies and appear to be a sensitive marker for intrapartal stress factors. The absence of an arterial/venous difference makes the sampling of cord blood easier but frequent haemolysis is a problem when using the standard method of analyses.