alexa Lactobionic Acid Produced by Zymomonas mobilis: Alterna
ISSN : 2153-2435

Pharmaceutica Analytica Acta
Open Access

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Research Article

Lactobionic Acid Produced by Zymomonas mobilis: Alternative to Prepare Targeted Nanoparticles

Ticiana Alexandra Valle1, Ângelo Adolfo Ruzza3, Marco Fabio Mastroeni1, Eloane Malvessi2, Maurício Moura da Silveira2, Ozair de Souza4 and Gilmar Sidnei Erzinger1*

1Department of Health and Environment, University of Joinville Region, SC, Brazil

2Biotechnology Institute, University of Caxias do Sul (INBio/UCS), RS, Brazil

3Department of Chemistry University Federal of Santa Catarina, SC, Brazil

4Department of MSc in Process Engineering, University of Joinville Region, SC, Brazil

*Corresponding Author:
Gilmar Sidnei Erzinger
Department of Health and Environment
University of Joinville Region, SC, Brazil
E-mail: [email protected]

Received date: February 28, 2013; Accepted date: March 18, 2013; Published date: March 22, 2013

Citation: Valle TA, Ruzza ÂA, Mastroeni MF, Malvessi E, da Silveira MM, et al. (2013) Lactobionic Acid Produced by Zymomonas mobilis: Alternative to Prepare Targeted Nanoparticles. Pharmaceut Anal Acta 4:220. doi: 10.4172/2153-2435.1000220

Copyright: © 2013 Valle TA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

The bacterium Zymomonas mobilis has the ability to produce several organic acids from mixtures of fructose and different aldoses as an alternative to glucose. One of these organic acids, lactobionic acid, is produced from the oxidation of lactose and is produced in equimolar amounts with sorbitol, a product of fructose reduction. Sorbitol is widely used in the food and pharmaceutical industry, while lactobionic acid has important applications in medicine and cosmetics. It has been reported in the literature that lactobionic acid has the potential for drug vectorization, particularly for anti-tumor drugs. The objective of this work is to show that lactobionic acid produced by Zymomonas mobilis can be used for targeted delivery of chemotherapeutic agents. Using analytical techniques such as HPLC, NMR and polarimetry, we showed that lactobionic acid produced in Zymomonas mobilis is of high purity (100%) when compared to the 97% pure lactobionic acid salt from Sigma®, which was used as a reference. In addition, the lactobionic acid made from Zymomonas was free of any contaminants or racemic isomers and had an open chain, suggesting its suitability for targeted delivery of nanoparticle drugs.

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