alexa Langerhans Cell Histiocytosis: A Rare Cause of Central Diabetes Insipidus
ISSN: 2165-8048

Internal Medicine: Open Access
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Case Report

Langerhans Cell Histiocytosis: A Rare Cause of Central Diabetes Insipidus

Weerachai Srivanichakorn1, Jantima Tanboon2 and Apiradee Sriwijitkamol3*
1Division of Ambulatory Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital
2Department of Pathology, Faculty of Medicine Siriraj Hospital
3Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University
*Corresponding Author : Apiradee Sriwijitkamol M.D
Division of Endocrine and Metabolism Department of Medicine
Faculty of Medicine, Siriraj Hospital, Mahidol University
Bangkok, Thailand
Tel: 662-419-7799
E-mail: [email protected]
Received November 17, 2012; Accepted February 10, 2012; Published February 14, 2012
Citation: Srivanichakorn W, Tanboon J, Sriwijitkamol A (2012) Langerhans Cell Histiocytosis: A Rare Cause of Central Diabetes Insipidus. Internal Med: Open Access 2:107. doi:10.4172/2165-8048.1000107
Copyright: © 2012 Srivanichakorn W, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Objective: To report adult patients with Langerhans cell histiocytosis who presented with a recent onset of polyuria, secondary amenorrhea and galactorrhea.
Methods: We report the clinical presentations, laboratory test results, imaging findings, histological findings and clinical courses of two cases of adult Langerhans cell histiocytosis.
Results: Our evaluation revealed the presence of central diabetes insipidus. Magnetic resonance imaging of the pituitary showed a thickening of the pituitary stalk. The skeleton survey, chest radiography and biochemistry revealed an osteolytic lesion at the frontal bone only in the first case; the other case was within normal limits. A biopsy was performed at the frontal bone in the first case and at the pituitary stalk in the other case. The pathologic examination confirmed the diagnosis of Langerhans cell histiocytosis. Replacement therapy with an intranasal administration of desmopressin can resolve symptoms. The stalk lesion decreased in size without specific treatment.
Conclusions: We reported two cases of adult Langerhans cell histiocytosis. These patients presented with central diabetes insipidus and galactorrhea. Both MRI findings revealed a unifocal infiltration of the infundibulum. The pathologic examination confirmed the diagnosis of Langerhans cell histiocytosis. Replacement therapy with an intranasal administration of desmopressin helped resolve symptoms. The stalk lesion decreased in size without specific treatment. Long-term follow up with proper supplementation to correct hormonal deficiencies may be the proper management in patients with isolated sellar or bone involvement that frequently experience a slower progression of the disease.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords