alexa Langerhans Cells in Oral Mucosa from Patients with Acquired Immunodeficiency Syndrome
ISSN: 2332-0877

Journal of Infectious Diseases & Therapy
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Research Article

Langerhans Cells in Oral Mucosa from Patients with Acquired Immunodeficiency Syndrome

Élia Cláudia de Souza Almeida1*, Renata Margarida Etchebehere2, Benito André da Silveira Miranzi3,
Jannaína Grazielle Pacheco Olegário4, Vitorino Modesto Santos5, Mario Leon Silva-vergara6, Gabriela Jerônimo Dal Moro7
and Maria das Graças Reis8
1Doctor of Health Science, Institute of Biological and Natural Sciences, Brazil
2Doctor of Surgical and Forensic Pathology, UFTM, Brazil
3Doctor of Dentistry, UNIUBE, Brazil
4Doctor in Health Science, Department of General Pathology, UFTM, Brazil
5Doctor of Internal Medicine, Department of Armed Forces Hospital and Catholic University, Brasília-DF, Brazil
6Doctor of Clinical Medicine, UFTM, Brazil
7Student of Nutrition Graduation, UFTM, Brazil
8Doctor of Science, Professor of Histology, UFTM, Brazil
Corresponding Author : Élia Cláudia de Souza Almeida
Institute of Biological and Natural Sciences
Triângulo Mineiro Federal University, Rua Cazuza 160
apto 102 Uberaba-MG, Brazil
Tel: 34-3318 5441
Fax: 34-3318 5462
E-mail: [email protected]
Received July 03, 2014; Accepted August 26, 2014; Published August 30, 2014
Citation: Almeida EC, Etchebehere RM, Miranzi BA, Pacheco Olegário JG, Santos VM, et al. (2014) Langerhans Cells in Oral Mucosa from Patients with Acquired Immunodeficiency Syndrome. J Infect Dis Ther 2:160. doi:10.4172/2332-0877.1000160
Copyright: © 2014 de Souza Almeida EC, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Background: Oral manifestations are common in patients with acquired immunodeficiency syndrome (AIDS).

Objectives: Compare the number of Langerhans cells and intensity of anti-CD1a expression in the mucous membranes of the oral cavities of the same patients with AIDS and HIV-negative individuals.

Materials and methods: Sixteen autopsied adults were investigated, including 11 with AIDS, and 5 HIV negative. We identified Langerhans cells in three oral regions of the same subject using an anti-CD1a antibody and quantified them in cells/mm2. Were applied normality tests and Mann-Whitney.

Results: The numbers of Langerhans cells in the AIDS patient group were less than in the control group, but didn't differ significantly between the two groups. The intensity of anti-CD1a expression was lower in patients with AIDS. Of the three areas, the greater intensity of CD1a cells were found in the masticatory mucosa.

Discussion: We observed a reduction of Langerhans cells in the oral mucosa of patients with AIDS and this is the first report, to our knowledge, that evaluate three different oral mucosal membranes in the same subject.

Conclusion: Our study suggests that AIDS influences on the depletion of Langerhans’ cells, particularly in the specialized mucosa, and the intensity of expression of anti- CD1a regardless of the type of oral mucosa.


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