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ISSN: 2329-6607

Cardiovascular Pharmacology: Open Access
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Research Article

Laparoscopic Sleeve Gasterectomy Reduces Inflammation and Cardiometabolic Risk in Obese Patients

FG Nazirov, ZR Khaybullina*, SH KH Khashimov and UM Makhmudov

Republican Specialized Center of Surgery named after academician V. Vakhidov, Ministry of Health Republic of Uzbekistan, Tashkent, Uzbekistan

Corresponding Author:
Khaybullina ZR
Republican Specialized Center of Surgery named after academician V. Vakhidov
Ministry of Health Republic of Uzbekistan, Tashkent, Uzbekistan
Tel: +998 71 239-47-95
E-mail: [email protected]

Received Date: November 01, 2016; Accepted Date: November 17, 2016; Published Date: November 23, 2016

Citation: Nazirov FG, Khaybullina ZR, Khashimov SK, Makhmudov UM (2016) Laparoscopic Sleeve Gasterectomy Reduces Inflammation and Cardiometabolic Risk in Obese Patients. Cardiovasc Pharm Open Access 5:200. doi: 10.4172/2329-6607.1000200

Copyright: © 2016 Khaybullina ZR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Obesity is associated with Metabolic Syndrome (MetS) and high cardiovascular risk as well as inflammation. Bariatric surgery is the most effective treatment of obesity and cardiovascular risk reduction. The aim of this research was to evaluate the Laparoscopic Sleeve Gasterectomy (LSG) effect on cardiometabolic risk factors, proinflammatory cytokines and oxidative stress markers in 25 women with morbid obesity (body mass index=45.4 ± 2.0 kg/m2). LSG is mini-invasive operation without radical reconstruction of gastrointestinal tract. It was established that after LSG there were no activation of inflammation, in contrast, there was reduction of proinflammatory cytokines (interleykin-6, tumor necrosis factor-alpha) and C-reactive protein in the blood at early (7th day) and late (3 month) period after operation. LSG led to a decrease in body weight and reduces cardiometabolic risk by normalizations of lipidomic profile (high-density lipoprotein cholesterol, triglyceride concentration in blood), optimizing the visceral fat tissue metabolism and reduction of inflammation and oxidative stress.

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