alexa Large Inflammatory Pericardial Effusion and Macrocytic Anemia in a Vogt-Koyanagi-Harada Patient | OMICS International| Abstract

Journal of Interventional and General Cardiology
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  • Case Report   
  • J Interv Gen Cardiol 2017, Vol 1(1): 106

Large Inflammatory Pericardial Effusion and Macrocytic Anemia in a Vogt-Koyanagi-Harada Patient

Elizabeth Onyekachi Ugoani1*, Lyse Anaelle Mohondiabeka Ossiadzi1, Jihad Raoui2, Seydou Sadou Maiga Hanatou1, Nouha Zerkaoui3, Nadia Fellat1 and Rokya Fellat1
1Department of Cardiology A, Ibn Sina Hospital, , Rabat, Morocco
2Department of Cardiology B, Souissi Maternity, , Rabat, Morocco
3Department of Ophtalmology B, Hospital Specialties, , Rabat, Morocco
*Corresponding Author : Elizabeth Onyekachi Ugoani, Department of Cardiology A, Ibn Sina Hospital, Rabat, Morocco, Tel: 0606823076, Email: [email protected]

Received Date: Dec 01, 2017 / Accepted Date: Dec 05, 2017 / Published Date: Dec 20, 2017


Vogt-Koyanagi-Harada (VKH) disease is a multisystemic autoimmune disease which targets pigmented tissues, especially the eyes, in a genetically susceptible individual (HLA-DR4 carrier). It is characterized by a bilateral, visionthreatening uveitis that evolves in 4 phases and by extraocular manifestations in other tissues containing melanin.
We report an association of complete VKH disease, vitamin B-deficient macrocytic anemia and a large, circumferential pericardial effusion in an 82-year old woman.
Although there is no known report, to the best of our knowledge, of cardiac manifestations in VKH disease, we argue that the inflammatory pericardial effusion we found is a cardiac manifestation of VKH disease since this disease is directed against melanin cells which can be found in the heart, and because we ruled out other common causes of pericardial effusion such as tuberculosis and neoplasm. Since genetic susceptibility to autoimmune diseases is a fertile environment for the development of auto-immune diseases, which frequently coexist, we suggest that our patient presents pernicious anemia associated with VKH disease.
In the light of the above observations, we suggest a systematic screening of VKH patients (Electrocardiogram, transthoracic echocardiography) for possible, potentially lethal cardiac manifestations before beginning VKH therapy.

Keywords: Vogt-Koyanagi-Harada disease; Uveitis, HLA-DR4; Pericardial effusion; Megaloblastic anemia, Vitamin B deficiency; Melanin

Citation: Ugoani EO, Mohondiabeka Ossiadzi LA, Raoui J, Seydou Sadou Maiga H, Zerkaoui N, et al. (2017) Large Inflammatory Pericardial Effusion and Macrocytic Anemia in a Vogt-Koyanagi-Harada Patient. J Interv Gen Cardiol. 1: 106.

Copyright: © 2017 Ugoani EO, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.