Lawsonia Inermis: Its Anatomy and its Antimalarial, Antioxidant and Human Breast Cancer Cells MCF7 ActivitiesFatiha El Babili1,3*, Alex Valentin2 and Christian Chatelain1
- *Corresponding Author:
- Fatiha El Babili
Laboratoire de Botanique-Mycologie
Faculté de Pharmacie, Université de Toulouse
118 Route de Narbonne, F-31062 Toulouse Cedex 9, France
E-mail: [email protected]
Received date: November 26, 2012; Accepted date: January 23, 2013; Published date: January 25, 2013
Citation: Babili FE, Bouajila J, Valentin A, Chatelain C (2013) Lawsonia Inermis: Its Anatomy and its Antimalarial, Antioxidant and Human Breast Cancer Cells MCF7 Activities. Pharmaceut Anal Acta 4:203. doi: 10.4172/2153-2435.1000203
Copyright: © 2013 Babili FE, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Anatomical features were highlighted to improve its identification, because although henna has some benefits, it has a wide spectrum of adverse effects from contact dermatitis to severe angioneurotic oedema and haemolysis. Serial extractions in petroleum ether, ethyl acetate, ethanol and water were performed on leaves of Lawsonia inermis and were studied. In these extracts, different chemical families were measured such as polyphenols (Gallic acid equivalent 71.7-129.6 g/Kg), tannins (Catechin equivalent 31.3-477.9 g/Kg), antocyanins (Cyanidin equivalent 0.75-5.48 mg/Kg) and flavonoids (Quercetin equivalent 16.2-85.6 g/Kg).
This present study reports ABTS/DPPH assay and antimalarial activity. We also checked activity against human breast cancer cells MCF7. The best extract with an antioxidant activity (IC50=6.9 ± 0.1 mg/L) was obtained by ethanol. We found an antimalarial activity of the petroleum ether extract (27 mg/L) of henna. Henna extracts showed activity against human breast cancer cells (MCF7) with the ethyl acetate extract (27 mg/L) and petroleum extract (22 mg/L).