alexa Lawsonia Inermis: Its Anatomy and its Antimalarial, Antioxidant and Human Breast Cancer Cells MCF7 Activities
ISSN : 2153-2435

Pharmaceutica Analytica Acta
Open Access

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Research Article

Lawsonia Inermis: Its Anatomy and its Antimalarial, Antioxidant and Human Breast Cancer Cells MCF7 Activities

Fatiha El Babili1,3*, Alex Valentin2 and Christian Chatelain1

1Faculté des Sciences Pharmaceutiques de Toulouse-Laboratoire de Botanique-Mycologie-Faculté de Pharmacie, 35 ch. des Maraîchers - F- 31062 Toulouse, France

2Laboratoire de Pharmacochimie des Substances Naturelles et Pharmacophores Redox, UMR 152, UPS, Université de Toulouse, 118 Route de Narbonne, F-31062 Toulouse Cedex 9, France

3Laboratoire des Interactions Moléculaires et Réactivité Chimique et Photochimique UMR CNRS 5623, Université de Toulouse, 118 Route de Narbonne, F-31062 Toulouse Cedex 9, France

*Corresponding Author:
Fatiha El Babili
Laboratoire de Botanique-Mycologie
Faculté de Pharmacie, Université de Toulouse
118 Route de Narbonne, F-31062 Toulouse Cedex 9, France
Tel: +33562259817
E-mail: [email protected]

Received date: November 26, 2012; Accepted date: January 23, 2013; Published date: January 25, 2013

Citation: Babili FE, Bouajila J, Valentin A, Chatelain C (2013) Lawsonia Inermis: Its Anatomy and its Antimalarial, Antioxidant and Human Breast Cancer Cells MCF7 Activities. Pharmaceut Anal Acta 4:203. doi: 10.4172/2153-2435.1000203

Copyright: © 2013 Babili FE, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Anatomical features were highlighted to improve its identification, because although henna has some benefits, it has a wide spectrum of adverse effects from contact dermatitis to severe angioneurotic oedema and haemolysis. Serial extractions in petroleum ether, ethyl acetate, ethanol and water were performed on leaves of Lawsonia inermis and were studied. In these extracts, different chemical families were measured such as polyphenols (Gallic acid equivalent 71.7-129.6 g/Kg), tannins (Catechin equivalent 31.3-477.9 g/Kg), antocyanins (Cyanidin equivalent 0.75-5.48 mg/Kg) and flavonoids (Quercetin equivalent 16.2-85.6 g/Kg).
This present study reports ABTS/DPPH assay and antimalarial activity. We also checked activity against human breast cancer cells MCF7. The best extract with an antioxidant activity (IC50=6.9 ± 0.1 mg/L) was obtained by ethanol. We found an antimalarial activity of the petroleum ether extract (27 mg/L) of henna. Henna extracts showed activity against human breast cancer cells (MCF7) with the ethyl acetate extract (27 mg/L) and petroleum extract (22 mg/L).

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