alexa Leader 8: Type 2 Diabetes Patients: A Comparison of Baseline Characteristics of Eastern and Western European Participants with Established Cardiovascular Disease in the LEADER Trial
ISSN: 2155-6156

Journal of Diabetes & Metabolism
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Research Article

Leader 8: Type 2 Diabetes Patients: A Comparison of Baseline Characteristics of Eastern and Western European Participants with Established Cardiovascular Disease in the LEADER Trial

Franek E1,2*, Rutten GEHM3, Orsted DD4, Baeres FMM4, Mota M5, Jacob S6, Bain SC7, Vidal J8 and Haluzik M9

1Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland

2Department of Internal Diseases, Endocrinology and Diabetology, Central Clinical Hospital MSW, Warsaw, Poland

3Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands

4Novo Nordisk, Denmark

5University of Medicine and Pharmacy of Craiova, Romania

6Kardio Metabolischen Instituts, Villingen--Schwenninge, Germany

7Institute of Life Science, Swansea, University Medical School, UK

8Universitat de Barcelona, Hospital Clinic Universitari, Barcelona, Spain

9Institute of Endocrinology and Institute of Medical Biochemistry and Laboratory Diagnostics of 1st Faculty of Medicine and General University Hospital, Charles University in Prague, Prague, Czech Republic

*Corresponding Author:
Dr. Edward Franek
Department of Internal Diseases
Endocrinology and Diabetology Central Clinical Hospital MSW
ul. Woloska 137, 02-507 Warsaw, Poland
Tel: +48225081405
E-mail: [email protected]

Received date: January 11, 2016; Accepted date: February 10, 2016; Published date: February 15, 2016

Citation: Franek E, Rutten GEHM, Orsted DD, Baeres FMM, Mota M, et al. (2016) Leader 8: Type 2 Diabetes Patients: A Comparison of Baseline Characteristics of Eastern and Western European Participants with Established Cardiovascular Disease in the LEADER Trial. J Diabetes Metab 7:646. doi: 10.4172/2155-6156.1000646

Copyright: © 2016 Franek E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Aim: The aim of the present analysis was to compare cardiovascular disease risk factors in patients from
different countries in Europe, using baseline data from the Liraglutide Effect and Action in Diabetes: Evaluation of
cardiovascular outcome Results (LEADER) trial.
Methods: Baseline characteristics and treatments were compared between the subgroup of patients with
established cardiovascular disease included in this study from the Eastern European Union (EEU), Western
European Union (WEU), and Russia and Serbia (Ru/Se).
Results: Glycaemic control was similar in the EEU and WEU, and poorest in Ru/Se, although WEU patients
were older and had longer diabetes duration. Systolic blood pressure was lowest in Ru/Se, whereas diastolic blood
pressure was lowest in the WEU. Control of dyslipidaemia was best in the WEU, and worst in Ru/Se. The percentage
of patients meeting all three targets for cardiovascular risk factors (HbA1c: ≤ 64 mmol/mol [8.0%], blood pressure:
<140/<90 mmHg and low-density lipoprotein [LDL]-cholesterol: 1.8 mmol/L [70 mg/dL]) was 9.7%, 6.4% and 3.2%
in the WEU, EEU and Ru/Se, respectively. Metformin and sulphonylurea treatment was more frequent in the EEU
than WEU and Ru/Se. Insulin, in turn, was used less frequently in the EEU than WEU and Ru/Se. The use of newer
drugs was small and differences could not be subjected to statistical analyses. Statins were used most frequently in
WEU countries and least frequently in Ru/Se.
Conclusion: The high cardiovascular risk patients in the WEU were older and had longer diabetes duration,
when compared with EEU and Ru/Se. Despite this, they had a lower body mass index (BMI), similar blood pressure
and better lipid control. Although the differences were small, the percentage of patients meeting all three treatment
targets was low across all regions studied.


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