alexa Learning how Mechanical Forces Regulate Lung Developmen
ISSN: 2161-0665

Pediatrics & Therapeutics
Open Access

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Learning how Mechanical Forces Regulate Lung Development:Opportunities for Translational Research

Juan Sanchez-Esteban*

Associate Professor of Pediatrics, Alpert Medical School of Brown University, USA

*Corresponding Author:
Juan Sanchez-Esteban
Associate Professor of Pediatrics
Alpert Medical School of Brown University, USA
E-mail: [email protected]

Received Date: August 01, 2012; Accepted Date: August 03, 2012; Published Date: August 06, 2012

Citation: Sanchez-Esteban J (2012) Learning how Mechanical Forces Regulate Lung Development: Opportunities for Translational Research. Pediat Therapeut 2:e115. doi:10.4172/2161-0665.1000e115

Copyright: © 2012 Sanchez-Esteban J. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Lung growth and development during fetal life are critical for extrauterine survival. Pulmonary hypoplasia secondary to congenital diaphragmatic hernia, oligohydramnios, etc, is an important cause of neonatal morbidity and mortality. In fact, pulmonary hypoplasia is the most common finding in neonatal autopsies. In addition, more than 20,000 babies are born every year in the United States before 27 weeks of gestation (canalicular stage of lung development). These disorders have in common an incomplete development of the lungs. Despite the improvement in neonatal care, these conditions can cause serious short-term and long-term morbidities. Currently, the management is primarily supportive and there is not specific treatment to stimulate the growth and development of the lungs.

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