Leptin and Autophagy: When the Two Masters Meet
- *Corresponding Author:
- Sami Dridi
Center of Excellence for Poultry Science
University of Arkansas, 1260 W. Maple Street
Fayetteville AR 72701, USA
E-mail: [email protected]
Received Date: February 28, 2015; Accepted date: March 28, 2015; Published date: March 30, 2015
Citation: Dridi S, Ishola P, Greene E, Nguyen P, Bottje W, et al. (2015) Leptin and Autophagy: When the Two Masters Meet. Anat Physiol 5:173. doi: 10.4172/2161-0940.1000173
Copyright: ©2015 Dridi S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse, distribution, and reproduction in any medium, provided the original author and source are credited.
Autophagy or cellular self-digestion, a lysosomal degradation pathway that is conserved from yeast to human, plays a key role in recycling cellular constituents, including damaged organelles. It also plays a pivotal role in the adaptation of cells to a plethora of distinct stressors including starvation. Leptin is an adipocytokine that is mostly produced by white adipose cells in mammals and functions as a hormonal sensing mechanism to inhibit feed intake and increase energy expenditure. In this review, we will describe the autophagy and leptin systems and summarized recent advances regarding their interactions in the regulation of energy homeostasis.