Leptin is Associated with Local Stiffness of the Carotid Artery in Overweight Patients with Type 2 DiabetesRyutaro Numaguchi1, Tomoaki Morioka1*, Yuko Yamazaki1, Satoshi Imamura1, Hiromi Urata1, Koka Motoyama1, Katsuhito Mori1, Shinya Fukumoto2, Tetsuo Shoji3, Masanori Emoto1 and Masaaki Inaba1
- *Corresponding Author:
- Tomoaki Morioka
Department of Metabolism, Endocrinology and Molecular Medicine
Osaka City University, Graduate School of Medicine, 1-4-3 Asahi-machi
Abeno-ku, Osaka, 545-8585 Japan
Tel: +81-6-6645- 3806
E-mail: [email protected]
Received date: November 05, 2015; Accepted date: November 24, 2015; Published date: November 28, 2015
Citation: Numaguchi R, Morioka T, Yamazaki Y, Imamura S, Urata H, et al. (2015) Leptin is Associated with Local Stiffness of the Carotid Artery in Overweight Patients with Type 2 Diabetes. J Diabetes Metab 6:627. doi: 10.4172/2155-6156.1000627
Copyright: © 2015 Numaguchi R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Objective: Besides its major role in the regulation of food intake and energy expenditure, leptin is involved in the pathogenesis of obesity-associated atherosclerosis. However, the clinical association between leptin and arterial stiffness, a surrogate marker for cardiovascular disease, has not been fully elucidated. This study aimed to investigate the association between the plasma leptin level and arterial stiffness in patients with type 2 diabetes.
Methods: Three hundred eighteen patients with type 2 diabetes, of which 155 were overweight (body mass index ≥ 25 kg/m2), were included in this study. Fasting plasma leptin levels were measured by enzyme-linked immunosorbent assay. Stiffness of the common carotid artery was evaluated by ultrasonography using Peterson’s elastic modulus (Ep) and arterial compliance (AC). Aortic stiffness was assessed by measuring the pulse wave velocity (PWV) in the heart-femoral segment.
Results: The mean age, duration of diabetes, and body mass index of the subjects were 60 years, 6 years, and 25.4 kg/m2, respectively. Plasma leptin levels were higher in the overweight group than in the lean group (median, 5.8 vs. 2.4 ng/mL). Multiple regression analyses adjusted by age, sex, body mass index, and other cardiovascular risk factors revealed that the plasma leptin level was independently associated with carotid Ep and AC in the overweight group, but not in the lean group. The plasma leptin level was not independently associated with aortic PWV in either group.
Conclusion: The plasma leptin level is associated with carotid arterial stiffness in overweight type 2 diabetes patients, independently of obesity and traditional cardiovascular risk factors. This study indicates an unfavorable effect of leptin on carotid arterial stiffness in diabetes with obesity.