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Lessons from Viral Superinfections for HIV-1 Vaccine Design | OMICS International | Abstract
ISSN 2155-6113

Journal of AIDS & Clinical Research
Open Access

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Review Article

Lessons from Viral Superinfections for HIV-1 Vaccine Design

Stephanie Jost*

Ragon Institute of MGH, MIT and Harvard, USA

*Corresponding Author:
Stephanie Jost
Ragon Institute of MGH
MIT and Harvard 400 Technology square
Cambridge MA 02139, USA
E-mail: [email protected]

Received Date: May 20, 2013; Accepted Date: June 20, 2013; Published Date: June 26, 2013

Citation: Jost S (2013) Lessons from Viral Superinfections for HIV-1 Vaccine Design. J AIDS Clinic Res S3:005. doi:10.4172/2155-6113.S3-005

Copyright: © 2013 Jost S. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Superinfection refers to a second viral infection in the context of a pre-existing adaptive immune response to prior infection with a viral strain that has not been cleared, the two viruses being genetically distinct yet belonging to the same genus. As such, this phenomenon provides unique settings to gain insights into the immune correlates of protection against HIV-1. The focus of this review is to discuss the current knowledge about immune responses to HIV-1 and to other viruses that are associated with partial or complete immunity to superinfection, or lack thereof, and how that could be applied to future HIV-1 vaccine strategies