Lessons Learned from the Differential Upregulation of 2Ã¢ÂÂ5Ã¢ÂÂ-Oligoadenylate Synthetase Genes in Systemic SclerosisGabriel Magno de Freitas Almeida*
Laboratorio de Vırus, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Antonio Carlos Avenue 6627, Pampulha 31270-901 Belo Horizonte, MG, Brazil
- *Corresponding Author:
- Gabriel Magno de Freitas Almeida
National Reference Laboratory for Aquatic Animal Diseases
Ministry of Fisheries and Aquaculture
Federal University of Minas Gerais
Belo Horizonte, Brazil
Tel: +33 (0)383 154 388
E-mail: [email protected]
Received date: May 05, 2015; Accepted date: June 06, 2015; Published date: June 11, 2015
Citation: Almeida GMF (2015) Lessons Learned from the Differential Upregulation of 2’5’-Oligoadenylate Synthetase Genes in Systemic Sclerosis. Immunome Res 11:005. doi:10.4172/1745-7580.S2.005
Copyright: ©2015 Almeida. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Precise regulation of the immune system is crucial for homeostasis maintenance. Autoimmunities are complex disorders that have in common alterations in immune homeostasis, and in order to be fully understood approaches that take into consideration their complexity are needed. In systemic sclerosis patients, levels of type I Interferons and 2’5’-oligoadenylate synthetase genes are found upregulated. In 2013, an approach that quantified each individual 2’5’-OAS gene in patients revealed that there is a differential upregulation of this gene family. The hypothesis is that during the disease patient cells are refractory to circulating type I Interferons and that an unknown stimuli is differentially inducing OAS2 and OASL genes. It can be taken as an example that the complexity of the immune system and its components must be taken into consideration to satisfactory understand autoimmunities.